Anti-UGT1A9 Polyclonal AntibodyAnti-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

英文名称	Anti-UGT1A9 Polyclonal Antibody
靶标	UGT1A9
别名	UGT1A9;UDPGT 1-9;UGT1*9;UGT1-09;UGT1.9;UGT-1I;UGT1I;lugP4;GNT1;UGT1
宿主	Rabbit
稀释比例	WB 1:1000-3000;IHC 1:100-300.
Gene ID	54600
保存	Store at -42°C. Avoid freeze / thaw cycles.
Swiss Prot	O60656
蛋白分子量	50/60kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.25.
亚细胞定位	Cytoplasm
免疫原	Recombinant protein of human UGT1A9
亚型	IgG
纯化方法	Affinity purification
背景资料	UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:12181437, PubMed:15472229, PubMed:15470161, PubMed:18004212, PubMed:18052087, PubMed:18674515, PubMed:19545173). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:12181437, PubMed:18004212). Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone (PubMed:15472229). Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties (PubMed:18052087, PubMed:19545173). Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II (PubMed:18674515). Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan (PubMed:12181437, PubMed:20610558). Also metabolizes mycophenolate, an immunosuppressive agent (PubMed:15470161, PubMed:18004212).Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
Public Immunogen Range	180-480aa
克隆类型	Polyclonal Antibody
交叉反应	Human;Mouse
应用	WB;IHC
规格	50ul100ul