Anti-EXOSC7 Polyclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

靶标	EXOSC7
别名	Exosome complex component RRP42;Exosome component 7;Ribosomal RNA-processing protein 42;p8;KIAA0116;RRP42;p8FLJ26543;KIAA0116hRrp42p;exosome component 7Rrp42p;exosome complex exonuclease RRP42;EAP1
宿主	Rabbit
稀释比例	WB 1:8000-12000.;IHC 1:50-200.
Gene ID	23016
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q15024
蛋白分子量	32kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4.
亚细胞定位	Nucleus Cytoplasm
免疫原	Recombinant protein of human EXOSC7
亚型	IgG
纯化方法	Octanoic acid-ammonium sulfate precipitation
背景资料	Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes.
Public Immunogen Range	1-291aa
克隆类型	Polyclonal Antibody
规格	50ul100ul