Anti-TIMELESS Polyclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

靶标	TIMELESS
别名	FLJ12640;FLJ20714;hTIM;Protein timeless homolog;TIM;TIM_HUMAN;TIM1;Timeless;timeless circadian clock 1;timeless circadian clock;timeless homolog;TIMELESS1;Tof1 homolog;timeless homolog (Drosophila);hTIMTIMELESS1
宿主	Rabbit
稀释比例	WB 1:1000-3000.
Gene ID	8914
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9UNS1
蛋白分子量	139kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.4.
亚细胞定位	Nucleus
免疫原	Recombinant protein of human TIMELESS
亚型	IgG
纯化方法	Affinity purification
背景资料	Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock (PubMed:9856465, PubMed:17141802, PubMed:17296725, PubMed:23418588, PubMed:26344098).Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17141802, PubMed:17296725).TIMELESS promotes TIPIN nuclear localization (PubMed:17141802, PubMed:17296725).Involved in cell survival after DNA damage or replication stress by promoting DNA repair (PubMed:17141802, PubMed:17296725, PubMed:26344098, PubMed:30356214).In response to double-strand breaks (DSBs), accumulates at DNA damage sites and promotes homologous recombination repair via its interaction with PARP1 (PubMed:26344098, PubMed:30356214).May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:15798197).Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock (PubMed:23418588).Negatively regulates CLOCK\|NPAS2-ARTNL/BMAL1\|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus (PubMed:9856465).May also play an important role in epithelial cell morphogenesis and formation of branching tubules (By similarity).
Public Immunogen Range	859-1209aa
克隆类型	Polyclonal Antibody
交叉反应	Human;Mouse;Rat
应用	WB
规格	50ul100ul