Anti-AF-6（B-5） Monoclonal AntibodyA-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

英文名称	Anti-AF-6（B-5） Monoclonal Antibody
靶标	ARRB1
别名	AF 6; AF6; AFAD_HUMAN; Afadin; ALL1-fused gene from chromosome 6 protein; FLJ34371; MLLT 4; MLLT4; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog Drosophila) translocated to 4; Myeloid/lymphoid or mixed lineage leukemia translocated to 4; Protein AF 6; Protein Af-6; Protein AF6; RP3 431P23.3; 5033403D15Rik; Gm314; I-afadin; Mllt4; S-afadin.
宿主	Rabbit
稀释比例	WB?1:100- 1:1000. IP 1-2 μg per 100-500 μg of total protein (1 ml of cell lysate).?IF ?1:50-1:500. IHC 1:50-1:500. ELISA 1:30-1:3000
Gene ID	4301
保存	Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Swiss Prot	P55196
蛋白分子量	207kDa
储存液	PBS with < 0.1% sodium azide and 0.1% gelatin.
亚细胞定位	Cell membrane
免疫原	Recombinant fusion protein of Human AF-6
亚型	IgG2aK
纯化方法	Affinity purification
克隆号	B-5
背景资料	The dynamics of a cell-cell interface such as tight junctions or adherensjunctions are important in many developmental, physiological and pathological processes. AF-6 (MLLT4: myeloid/lymphoid or mixed-lineage leukemia translocated to 4) is a 1,612 amino acid protein that contains two N-terminal Ras binding domains (RBD) and a GLGF motif, and is implicated in Ras-mediated signaling events occurring at peripheral cell-cell junctions. AF-6 interacts with F-Actin and Profilin in cell-cell junctions, and may modulate Actin modeling near adhesion complexes. Furthermore, AF-6 coordinates junction adhesion molecule (JAM) recruitment to intercellular junctions through a PDZ domain. Developing mice deficient in AF-6 activity display a loss of neuroepithelial polarity, suggesting that AF-6 activity is an important regulator of cell-cell junctions that influence apical/basolateral asymmetry
克隆类型	Monoclonal antibody
交叉反应	HumanRatMouse
应用	WBELISAIHC-PIFIP
规格	1ml