Anti-RBM4 Polyclonal AntibodyAnti-R-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

英文名称	Anti-RBM4 Polyclonal Antibody
别名	dkfzp547k0918;hLark;lark;Lark homolog;lark homologue;mgc75138;RBM4;rbm4 lark;RBM4_HUMAN;RNA binding motif 4;RNA binding motif 4a;RNA-binding motif protein 4;RNA-binding motif protein 4a;RNA-binding protein 4;
宿主	Rabbit
稀释比例	WB 1:1000-3000.
Gene ID	5936
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9BWF3
蛋白分子量	16/20/40kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Nucleus
免疫原	Recombinant protein of human RBM4
亚型	IgG
纯化方法	Affinity purification
背景资料	RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro.
Public Immunogen Range	1-365aa
克隆类型	Polyclonal Antibody
交叉反应	HumanRatMouse
应用	WB
规格	50ul100ul