Anti-SGO1 Polyclonal AntibodyAnti-S-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

英文名称	Anti-SGO1 Polyclonal Antibody
别名	hSgo 1;hSgo1;NY BR 85;Serologically defined breast cancer antigen NY BR 85;Serologically defined breast cancer antigen NY-BR-85;SGO 1;SGO;SGO L1;SGO1;SGOL 1;SGOL1;SGOL1_HUMAN;Shugoshin 1AB protein;Shugoshin 1CD protein;Shugoshin 1EFprotein;Shugoshin 1GH protein;Shugoshin 1KL protein;Shugoshin like 1 (S. pombe);Shugoshin like 1;Shugoshin-like 1;
宿主	Rabbit
稀释比例	IHC 1:50-200.
Gene ID	151648
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q5FBB7
蛋白分子量	25/29/31/34/35/60/64kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Nucleus Cytoplasm
免疫原	A synthetic peptide of human SGO1
亚型	IgG
纯化方法	Octanoic acid-ammonium sulfate precipitation
背景资料	Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.
Public Immunogen Range	385-435/561aa
克隆类型	Polyclonal Antibody
交叉反应	Human
应用	IHC
规格	50ul100ul