Anti-phospho-LATS2(Ser83) Polyclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

英文名称	Anti-phospho-LATS2(Ser83) Polyclonal Antibody
别名	Kinase phosphorylated during mitosis;KPM;Large tumor suppressor homolog 2;Large tumor suppressor homolog 2 Drosophila;LATS large tumor suppressor Drosophila homolog 2
宿主	Rabbit
稀释比例	WB 1:500-2000. ELISA 1:5000-10000. IHC-P 1:100-500. IHC-F 1:100-500. IF 1:100-500.
Gene ID	26524
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9NRM7
蛋白分子量	120-150kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm
免疫原	KLH conjugated Synthesised phosphopeptide derived from human LATS2 around the phosphorylation site of Ser83
亚型	IgG
纯化方法	Affinity purification
背景资料	Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
克隆类型	Polyclonal Antibody
交叉反应	HumanPigCowHorseDogRatMouse
应用	WBIFIHC-FIHC-PELISA
规格	50ul100ul