Anti-APP Polyclonal AntibodyAnti-AP-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

英文名称	Anti-APP Polyclonal Antibody
别名	Soluble APP-alpha;Soluble APP-beta;A4 amyloid protein;A4;AAA;ABETA;ABPP;AD 1;AD1;Alzheimer disease 1;Alzheimer disease;Alzheimer's disease amyloid protein;Amyloid beta (A4) precursor protein;APP;APP I;APPI;Beta amyloid peptide
宿主	Rabbit
稀释比例	WB 1:500-2000. ELISA 1:5000-10000. IHC-P 1:100-500. IHC-F 1:100-500. ICC 1:100-500. IF 1:100-500.
Gene ID	351
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P05067
蛋白分子量	87kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Nucleus Cell membrane Cytoplasm Extracellular matrix
免疫原	KLH conjugated synthetic peptide derived from of human APP
亚型	IgG
纯化方法	Affinity purification
背景资料	Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons.Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity.
克隆类型	Polyclonal Antibody
交叉反应	HumanPredicted:Mouse Chicken Dog Pig Cow Horse Rabbit SheepRat
应用	WBIFICCIHC-FIHC-PELISA
规格	50ul100ul