Anti-HDAC4(N-term) Monoclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

英文名称	Anti-HDAC4(N-term) Monoclonal Antibody
别名	AHO3;BDMR;HA6116;HD4;HDAC-4;HDAC-A;HDACA
宿主	Mouse
稀释比例	WB 1:1000.
Gene ID	9759
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P56524
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
蛋白分子量	119kDa
亚细胞定位	Cytoplasm Nucleus
免疫原	Purified recombinant human HDAC4 protein fragments expressed in E.coli
亚型	IgG2a
性状	液体
纯化方法	Affinity purification
克隆号	4A3-H7-C6
背景资料	Chromatin is a highly specialized structure composed of tightly compacted chromosomal DNA. Gene expression within the nucleus is controlled, in part, by a host of protein complexes which continuously pack and unpack the chromosomal DNA. One of the known mechanisms of this packing and unpacking process involves the acetylation and deacetylation of the histone proteins comprising the nucleosomal core. Acetylated histone proteins confer accessibility of the DNA template to the transcriptional machinery for expression. Histone deacetylases (HDACs) are chromatin remodeling factors that deacetylate histone proteins and thus, may act as transcriptional repressors. HDACs are classified by their sequence homology to the yeast HDACs and there are currently 2 classes. Class I proteins are related to Rpd3 and members of class II resemble Hda1p.HDAC4 is a class II histone deacetylase containing 1084 amino acid residues. HDAC4 has been shown to interact with NCoR. HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation. HDAC4 has also been shown to interact with other deacetylases such as HDAC3 as well as the corepressors NcoR and SMART.
Public Immunogen Range	Purified recombinant human HDAC4 protein fragments expressed in E.coli
克隆类型	Monoclonal Antibody
交叉反应	Human
应用	WBIP
规格	50ul100ul