Anti-FGR Polyclonal Antibody-上海极威生物商城-Elisa试剂盒,白介素ELISA试剂盒,酶联免疫试剂盒,Gibco胎牛血清,Hyclone胎牛血清,胎牛血清等实验耗材一站式采购平台

产品简介

靶标	FGR
别名	c fgr; c fgr protooncogene; c src 2 proto oncogene; c src2; Fgr; FGR_HUMAN; FLJ43153; Gardner Rasheed feline sarcoma viral (v fgr); Gardner Rasheed feline sarcoma viral (v fgr) oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; p55 c fgr protein; P55 FGR; P55-FGR; p55c fgr; p58-Fgr; p58c fgr; p58c-Fgr; Proto oncogene c Fgr; Proto oncogene tyrosine protein kinase FGR; Proto-oncogene c-Fgr; SRC 2; SRC2; Tyrosine protein kinase Fgr; Tyrosine-protein kinase Fgr;
宿主	Rabbit
稀释比例	IHC 1:100-300.
Gene ID	2268
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P09769
蛋白分子量	59kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Cell membrane
免疫原	A synthetic peptide of human FGR
亚型	IgG
纯化方法	Affinity purification
背景资料	Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity).
Public Immunogen Range	15-65/529
克隆类型	Polyclonal Antibody
交叉反应	Human
应用	IHC
规格	50ul100ul