Human papillomavirus type 16 isolate Amazonian, complete genome
GenBank: HM057182.1
FASTA Graphics
Go to:
LOCUS       HM057182                7915 bp    DNA     circular VRL 25-JUL-2016
DEFINITION  Human papillomavirus type 16 isolate Amazonian, complete genome.
ACCESSION   HM057182
VERSION     HM057182.1
KEYWORDS    .
SOURCE      Human papillomavirus type 16
  ORGANISM  Human papillomavirus type 16
            Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
            Papovaviricetes; Zurhausenvirales; Papillomaviridae;
            Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 9.
REFERENCE   1  (bases 1 to 7915)
  AUTHORS   Barbosa Filho,R.A.A., Borborema Santos,C.M. and Astolfi Filho,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (03-APR-2010) Biotechnology, Molecular Diagnostic's Lab,
            Amazonas' Federal University, Av. Gen. Rodrigo Otavio Jordao Ramos,
            Manaus, Amazonas, Brazil
FEATURES             Location/Qualifiers
     source          1..7915
                     /organism="Human papillomavirus type 16"
                     /mol_type="genomic DNA"
                     /isolate="Amazonian"
                     /host="Homo sapiens"
                     /db_xref="taxon:333760"
                     /country="Brazil"
                     /collection_date="Mar-2007"
                     /note="type: 16"
     misc_feature    1..81
                     /note="long control region (LCR)"
     gene            82..558
                     /gene="E6"
     CDS             82..558
                     /gene="E6"
                     /note="transforming protein"
                     /codon_start=1
                     /product="E6"
                     /protein_id="ADH94042.1"
                     /translation="MHQKRTAMFQDPQERPTKLPDLCTELQTTIHDIILECVYCKQQL
                     LRREVYDFAFRDLCIVYRDGNPYAVCDKCLKFYSKISEYRYYCYSLYGTTLEQQYNKP
                     LCDLLIRCINCQKPLCPEERQRHLDKKQRFHNIRGRWTGRCMSCCRSSRTRRETQL"
     gene            561..857
                     /gene="E7"
     CDS             561..857
                     /gene="E7"
                     /note="transforming protein"
                     /codon_start=1
                     /product="E7"
                     /protein_id="ADH94043.1"
                     /translation="MHGDTPTLHEYMLDLQPETTDLYCYEQSPFSSEEEDEIDGPAGQ
                     AEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP"
     gene            864..2813
                     /gene="E1"
     CDS             864..2813
                     /gene="E1"
                     /note="replication protein"
                     /codon_start=1
                     /product="E1"
                     /protein_id="ADH94044.1"
                     /translation="MADPAGTNGEEGTGCNGWFYVEAVVEKKTGDAISDDENENDSDT
                     GEDLVDFIVNDNDYLTQAETETAHALFTAQEAKEHRDAVQVLKRKYLGSPLSDISGCV
                     DNNISPRLKAICIEKQSRAAKRRLFESEDSGYGNTEVETQQMLQVEGRHETETPCSQY
                     SGGSGGGSSQYSSGSGGEGVSERHAICQTPLTNILNVLKTSNAKAAMLAKFKELYGVS
                     FSELVRPFKSNKSTCCDWCIAAFGLTPSIADSIKTLLQQYCLYLHIQSLACSWGMVVL
                     LLVRYKCGKNRETIEKLLSKLLCVSPMCMMIEPPKLRSTAAALYWYKTGMSNISEVYG
                     DTPEWIQRQTVLQHSFNDCTFELSQMVQWAYDNDIVDDSEIAYKYAQLADTNSNASAF
                     LKSNSQAKIVKDCATMCRHYKRAEKKQMSMSQWIKYRCDRVDDGGDWKQIVMFLRYQG
                     VDFMSFLTALKRFLQGIPKKNCILLYGAANTGKSLFGMSLMKFLQGSVICFVNSKSHF
                     WLQPLADAKIGMLDDATVPCWNYIDDNLRNALDGNLVSMDVKHRPLVQLKCPPLLITS
                     NINAGTDSRWPYLHNRLVVFTFPNEFPFDENGNPVYELNDKNWKSFFSRTWSRLSLHE
                     DEDKENDGDSLPTFKCVSGQNTNTL"
     gene            2755..3852
                     /gene="E2"
     CDS             2755..3852
                     /gene="E2"
                     /note="regulatory protein"
                     /codon_start=1
                     /product="E2"
                     /protein_id="ADH94045.1"
                     /translation="METLCQRLNVCQDKILTHYENDSTDLRDHIDYWKQMRLECAIYY
                     KAREMGFKHINHQVVPTLAVSKNKALQAIELQLTLETIYNSQYSNEKWTLQDVSLEVY
                     LTAPTGCIKKHGYTVEVQFDGDICNTMHYTNWKYIYICEETSVTVVEGQVDYYGLYYV
                     HEGIQTYFVQFKDDAEKYSKNKVWEVHAGGQVILCPTSVFSSDEVSSAEIIRQHLANH
                     SAATHPKAVALGTKETQTTIQRPRSEPDTGNPCHTNKLLHRDSVDSAPILTAVNSSHK
                     GRINCNSNTTPIVHLKGDANTLKCLRYRFKKHCKLYTAVSSTWHWTGHNVKHKSAIVT
                     LTYDSECQREQFLSQVKIPKTITVSTGFMSI"
     gene            <3332..3619
                     /gene="E4"
     CDS             <3332..3619
                     /gene="E4"
                     /note="transforming protein; start codon not determined"
                     /codon_start=1
                     /product="E4"
                     /protein_id="ADH94048.1"
                     /translation="YYVLHLCLAATKYPLLKLLGSTWPTTPPRPIPKPSPWAPKKHRR
                     LSSDQDQSQTPETPATPISCCTETQWTVLQSSLQLTAHTKDGLTVIVTLHP"
     gene            3849..4100
                     /gene="E5"
     CDS             3849..4100
                     /gene="E5"
                     /note="transforming protein"
                     /codon_start=1
                     /product="E5"
                     /protein_id="ADH94046.1"
                     /translation="MTNLDTTSTTLLACFLLCFCVLLCVCLLIRPLLLSVSTYTSLIL
                     LVLLLWITAASAFRCFIVYILFVYIPLSLIHTHARFLIT"
     gene            4222..5643
                     /gene="L2"
     CDS             4222..5643
                     /gene="L2"
                     /note="minor capsid protein"
                     /codon_start=1
                     /product="L2"
                     /protein_id="ADH94049.1"
                     /translation="MRHKRSAKRTKRASATQLYKTCKQAGTCPPDIIPKVEGKTIADQ
                     ILQYGSMGVFFGGLGIGTGSGTGGRTGYIPLGTRPPTATDTLAPVRPPLTVDPVGPSD
                     PSIVSLVEETSFIDVGAPTPVPSIPPDVSGFSITTSTDTTPAILDINNTVTTVTTHNN
                     PTFTDPSVLQPPTPAETGGHFTLSSSTISTHNYEEIPMDTFIVSTNPNTVTSSTPIPG
                     SRPVARLGLYSRTTQQVKVVDPAFVTTPTKLITYDNPAYEGIDVDNTLYFPSNDNSIN
                     IAPDPDFLDIVALHRPALTSRRTGIRYSRIGNKQTLRTRSGKSIGAKVHYYYDLSTIN
                     PAEEIELQTITPSTYTTASHAASPTSINNGLYDIYADDFITDTSTTPVPSIPSTSLSG
                     YIPANTTIPFGGAYNIPLVSGPDIPINTTDQTPSLIPIVPGSPQYTIIADGGDFYLHP
                     SYYMLRKRRKRLPYFFSDVSLAA"
     gene            5546..7141
                     /gene="L1"
     CDS             5546..7141
                     /gene="L1"
                     /note="major capsid protein"
                     /codon_start=1
                     /product="L1"
                     /protein_id="ADH94047.1"
                     /translation="MEVTFIYILVITCYENDVNVYHIFFQMSLWLPSEATVYLPPVPV
                     SKVVSTDEYVARTNIYYHAGTSRLLAVGHPYFPIKKPNNNKILVPKVSGLQYRVFRIY
                     LPDPNKFGFPDTSFYNPDTQRLVWACVGVEVGRGQPLGVGISGHPLLNKLDDTENASA
                     YAANAGVDNRECISMDYKQTQLCLIGCKPPIGEHWGKGSPCNNVAVNPGDCPPLELIN
                     TVIQDGDMVDTGFGAMDFTTLQANKSEVPLDICTSICKYPDYIKMVSEPYGDSLFFYL
                     RREQMFVRHLFNRAGAVGENVPDDLYIKGSGSTANLASSNYFPTPSGSMVTSDAQIFN
                     KPYWLQRAQGHNNGICWGNQLFVTVVDTTRSTNMSLCAAISTSETTYKNTNFKEYLRH
                     GEEYDLQFIFQLCKITLTADVMTYIHSMNSTILEDWNFGLQPPPGGTLEDTYRFVTSQ
                     AIACQKHTPPAPKEDPLKKYTFWEVNLKEKFSADLDQFPLGRKFLLQAGFKAKPKFTL
                     GKQKATPTTSSTSTTAKRKKRKL"
     misc_feature    7142..7915
                     /note="long control region (LCR)"
ORIGIN      
        1 actacaataa ttcatgtata aactaagggt gtaaccgaaa tcggttgaac cggaaccggt
       61 tagtataaaa gcagacattt tctgcaccaa aagagaactg caatgtttca ggacccacag
      121 gagcgaccca caaagttacc agatttatgc acagagctgc aaacaactat acatgatata
      181 atattagaat gtgtgtactg caagcaacag ttactgcgac gtgaggtata tgactttgct
      241 tttcgggatt tatgcatagt atatagagat gggaatccat atgcagtgtg tgataaatgt
      301 ttaaagtttt attctaaaat tagtgagtat agatattatt gttatagttt gtatggaaca
      361 acattagaac agcaatacaa caaaccgttg tgtgatttgt taattaggtg tattaactgt
      421 caaaagccac tgtgtcctga agaaaggcaa agacatctgg acaaaaagca aagattccat
      481 aatataaggg gtcggtggac cggtcgatgt atgtcttgtt gcagatcatc aagaacacgt
      541 agagaaaccc agctgtaatc atgcatggag atacacctac attgcatgaa tatatgttag
      601 atttgcaacc agagacaact gatctctact gttatgagca atcgcccttc agctcagagg
      661 aggaggatga aatagatggt ccagctggac aagcagaacc ggacagagcc cattacaata
      721 ttgtaacctt ttgttgcaag tgtgactcta cgcttcggtt gtgcgtacaa agcacacacg
      781 tagacatccg tacgttggaa gacctgttaa tgggcacact aggaattgtg tgccccatct
      841 gttctcagaa accataatct accatggctg atcctgcagg taccaatggg gaagagggta
      901 cgggatgtaa tggatggttt tatgtagagg ctgtagtgga aaaaaaaaca ggggatgcta
      961 tatcagatga cgagaacgaa aatgacagtg atacaggtga agatttggta gattttatag
     1021 taaatgataa tgattattta acacaggcag aaacagagac agcacatgcg ttgtttactg
     1081 cacaggaagc aaaagaacat agagatgcag tacaggttct aaaacgaaag tatttgggta
     1141 gtccacttag tgatattagt ggatgtgtag acaataatat tagtcctaga ttaaaagcta
     1201 tatgtataga aaaacaaagt agagctgcaa aaaggagatt atttgaaagc gaagacagcg
     1261 ggtatggcaa tactgaagtg gaaactcagc agatgttaca ggtagaaggg cgccatgaga
     1321 ctgaaacacc atgtagtcag tatagtggtg gaagtggggg tggtagcagt cagtatagta
     1381 gtggaagtgg gggagagggt gttagtgaaa gacacgctat atgccaaaca ccacttacaa
     1441 atattttaaa tgtactaaaa actagtaatg caaaggcagc aatgctagca aaatttaaag
     1501 agttatacgg ggtgagtttt tcagaattag taagaccatt taaaagtaat aaatcaacgt
     1561 gttgcgattg gtgtattgct gcatttggac ttacacctag tatagctgac agtataaaaa
     1621 cattattaca acaatattgt ttatatttac acattcaaag tttagcatgt tcatggggaa
     1681 tggttgtgtt actattagta agatataaat gtggaaaaaa tagagaaaca attgaaaaat
     1741 tgctgtctaa actattatgt gtgtctccaa tgtgtatgat gatagagcct ccaaaattgc
     1801 gtagtacagc agcagcatta tattggtata aaacaggtat gtcaaatatt agtgaagtgt
     1861 atggagacac gccagaatgg atacaaagac aaacagtatt acaacatagt tttaatgatt
     1921 gtacatttga attatcacag atggtacaat gggcctacga taatgacata gtagacgata
     1981 gtgaaattgc atataaatat gcacaattgg cagacactaa tagtaatgca agtgcctttt
     2041 taaaaagtaa ttcacaggca aaaattgtaa aggattgtgc aacaatgtgt agacattata
     2101 aacgagcaga aaaaaaacaa atgagtatga gtcaatggat aaaatataga tgtgataggg
     2161 tagatgatgg aggtgattgg aagcaaattg ttatgttttt aaggtatcaa ggtgtagact
     2221 ttatgtcatt tttaactgca ttaaaaagat ttttgcaagg catacctaaa aaaaattgca
     2281 tattactata tggtgcagct aacacaggta aatcattatt tggtatgagt ttgatgaaat
     2341 ttttgcaagg gtctgtaata tgttttgtaa attctaaaag ccatttttgg ttacaaccat
     2401 tagcagatgc caaaataggt atgttagatg atgctacagt gccctgttgg aactacatag
     2461 atgacaattt aagaaatgca ttggatggaa atttagtttc tatggatgta aagcatagac
     2521 cattggtaca actaaaatgc cctccattat taattacatc taacattaat gctggtacag
     2581 attccaggtg gccttattta cataatagat tggtggtgtt tacatttcca aatgagtttc
     2641 catttgacga aaacggaaat ccagtgtatg agcttaatga taagaactgg aaatcctttt
     2701 tctcaaggac gtggtccaga ttaagtttgc acgaggacga ggacaaggaa aacgatggag
     2761 actctttgcc aacgtttaaa tgtgtgtcag gacaaaatac taacacatta tgaaaatgat
     2821 agtacagacc tacgtgacca tatagactat tggaaacaaa tgcgcctaga atgtgctatt
     2881 tattacaagg ccagagaaat gggatttaaa catattaacc accaggtggt gccaacactg
     2941 gctgtatcaa agaataaagc attacaagca attgaactgc aactaacgtt agaaacaata
     3001 tataactcac aatatagtaa tgaaaagtgg acattacaag atgttagcct tgaagtgtat
     3061 ttaactgcac caacaggatg tataaaaaaa catggatata cagtggaagt gcagtttgat
     3121 ggagacatat gcaatacaat gcattataca aactggaaat atatatatat ttgtgaagaa
     3181 acatcagtaa ctgtggtaga gggtcaagtt gactattatg gtttatatta tgttcatgaa
     3241 ggaatacaaa catattttgt gcagtttaaa gatgatgcag aaaaatatag taaaaataaa
     3301 gtatgggaag ttcatgcggg tggtcaggta atattatgtc ctacatctgt gtttagcagc
     3361 gacgaagtat cctctgctga aattattagg cagcacttgg ccaaccactc cgccgcgacc
     3421 catcccaaag ccgtcgcctt gggcaccaaa gaaacacaga cgactatcca gcgaccaaga
     3481 tcagagccag acaccggaaa cccctgccac accaataagt tgttgcacag agactcagtg
     3541 gacagtgctc caatcctcac tgcagttaac agctcacaca aaggacggat taactgtaat
     3601 agtaacacta cacccatagt acatttaaaa ggtgatgcta atactttaaa atgtttaaga
     3661 tatagattta aaaagcattg taaattgtat acagcagtgt cgtctacatg gcattggaca
     3721 ggacataatg taaaacataa aagtgcaatt gttacactta catatgatag tgaatgtcaa
     3781 cgggaacaat ttttgtctca agttaaaata ccaaaaacta ttacagtgtc tactggattt
     3841 atgtctatat gacaaacctt gatactacat ccacaacatt actggcgtgc tttttgcttt
     3901 gcttttgtgt gcttttgtgt gtctgcctat taatacgtcc gctgcttttg tctgtgtcta
     3961 catacacatc attaatacta ttggtattat tattgtggat aacagcagcc tctgcgttta
     4021 ggtgttttat tgtatatatt ttatttgttt atataccatt atctttaata catacacatg
     4081 cacgcttctt aattacataa tgtatatgta cataatgtaa ttgttacata taattgttgt
     4141 atatgataac ttactgattt ttttttttat ttttatatat atagtttttt tttttatttg
     4201 tttgtttgtt ttttaataaa catgcgacac aaacgttctg caaaacgcac aaaacgtgca
     4261 tcggccaccc aactttataa aacatgcaaa caagcaggta catgtccacc tgacattata
     4321 cctaaggttg aaggcaaaac tattgctgat caaatattac aatatggaag tatgggtgta
     4381 ttttttggtg ggttaggaat tggaacaggg tcaggtacag gcggacgcac tgggtatatt
     4441 ccattaggaa caaggcctcc cacagctaca gatacacttg ctcctgtaag acccccttta
     4501 acagtagatc ctgtgggccc ttctgatcct tctatagttt ctttagtgga agaaactagt
     4561 tttattgatg ttggtgcacc aacacctgta ccttccattc ccccagatgt atcaggattt
     4621 agtatcacaa cttcaactga taccacacct gctatattag atattaataa tactgttact
     4681 actgttacta cacataataa tcccactttt actgacccat ctgtattgca gcctccaaca
     4741 cctgcagaaa ctggagggca ttttacactt tcatcatcca ctattagtac acataattat
     4801 gaagaaattc ctatggatac atttattgtt agcacaaacc ctaacacagt aactagtagc
     4861 acacccatac cagggtctcg cccagtggca cgccttggat tatatagtcg cacaacacaa
     4921 caagttaaag ttgtagaccc tgcttttgta accactccca ctaaacttat tacatatgat
     4981 aatcctgcat atgaaggtat agatgtggat aatacattat attttcctag taatgataat
     5041 agtattaata tagctccaga tcctgacttt ttggatatag ttgctttaca taggccagca
     5101 ttaacctcta ggcgtactgg cattagatac agtagaattg gtaataaaca aacactacgt
     5161 actcgtagtg gaaaatctat aggtgctaag gtacattatt attatgattt aagtactatt
     5221 aatcctgcag aagaaataga attacaaact ataacacctt ctacatatac taccgcttca
     5281 catgcagcct cacccacttc tattaataat ggattatatg atatttatgc agatgacttt
     5341 attacagata cttctacaac cccagtacca tctataccct ctacatcctt atcaggttat
     5401 attcctgcaa atacaacaat tccttttggt ggtgcataca atattccttt agtatcaggt
     5461 cctgatatac ccattaatac aactgaccaa actccttcat taattcctat agttccaggg
     5521 tctccacaat atacaattat tgctgatgga ggtgactttt atttacatcc tagttattac
     5581 atgttacgaa aacgacgtaa acgtttacca tatttttttt cagatgtctc tttggctgcc
     5641 tagcgaggcc actgtctact tgcctcctgt cccagtatct aaagttgtaa gcacggatga
     5701 atatgttgca cgcacaaaca tatattatca tgcaggaaca tccagactac ttgcagttgg
     5761 acatccctat tttcctatta aaaaacctaa caataacaaa atattagttc ctaaagtatc
     5821 aggattacaa tacagggtat ttagaatata tttacctgac cccaataagt ttggttttcc
     5881 tgacacctca ttttacaatc cagatacaca gcggctggtt tgggcctgtg taggtgttga
     5941 ggtaggtcgt ggtcagccat taggtgtggg cattagtggc catcctttat taaataaatt
     6001 ggatgacaca gaaaatgcta gtgcttatgc agcaaatgca ggtgtggata atagagaatg
     6061 tatatctatg gattacaaac aaacacaatt gtgtttaatt ggttgcaaac cacctatagg
     6121 ggaacactgg ggcaaaggat ccccatgtaa caatgttgca gtaaatccag gtgattgtcc
     6181 accattagag ttaataaaca cagttattca ggatggtgat atggttgata ccggctttgg
     6241 tgctatggac tttactacat tacaggctaa caaaagtgaa gttccactgg atatttgtac
     6301 gtctatttgc aaatatccag attatattaa aatggtgtca gagccatatg gcgacagctt
     6361 atttttttat ttacgaaggg aacaaatgtt tgttagacat ttatttaata gggctggtgc
     6421 tgttggtgaa aatgtaccag acgatttata cattaaaggc tctgggtcta ctgcaaattt
     6481 agccagttca aattattttc ctacacctag tggttctatg gttacctctg atgcccaaat
     6541 atttaataaa ccatattggt tgcaacgagc acagggtcat aacaatggca tttgttgggg
     6601 taaccaacta tttgttactg ttgttgatac tacacgcagt acaaatatgt cattatgtgc
     6661 tgccatatct acttcagaaa ctacatataa aaatactaac tttaaagagt acctacgaca
     6721 tggggaggaa tatgatttac agtttatttt tcaactgtgc aaaataacct taactgcaga
     6781 cgttatgaca tacatacatt ctatgaattc cactattttg gaggactgga attttggttt
     6841 acaacctccc ccaggaggca cactagaaga tacttatagg tttgtaacat cccaggcaat
     6901 tgcttgtcaa aaacatacac ctccagcacc taaagaagat ccccttaaaa aatatacttt
     6961 ttgggaagta aatttaaaag aaaagttttc tgcagaccta gatcagtttc ctttaggacg
     7021 caaattttta ctacaagcag gatttaaggc caaaccaaaa tttacattag gaaaacaaaa
     7081 agctacaccc accacctcat ctacctctac aactgctaaa cgcaaaaaac gtaagctgta
     7141 agtattgtat gtatgttgaa ttagtgttgt atgttgttta tatgtttgta tgtgcttgta
     7201 tgtgcttgta aatattgagt tgtatgtgtg tttgtatgta tggtataata aacacgtgtg
     7261 tatgtgtttt taaatgcgtg tgtgtatgtg tttttaaatg cttgtgtaac tattgtgtca
     7321 tgcaacataa ataaacttat tgtttcaaca cctactaatt gtgttgtggt tattcattgt
     7381 atataaacta tatttgctac atcctgtttt tgttttatat atactatatt ttgtagcgcc
     7441 agcggccatt ttgtagcttc aaccgaattc ggttgcatgc tttttggcac aaaatgtatt
     7501 tttttaaata gttctatgtc agcaactata gtttaaactt gtacgtttcc tgcttgccat
     7561 gcgtgccaaa tccctgtttt cctgacctgc actgcttgcc aaccattcca ttgttttttg
     7621 cactgcacta tgtgcaacta ctgaatcact atgtacattg tgtcatataa aataaatcac
     7681 tatgcgccaa cgccttaaat accgctgtta ggcacatatt tttggcttgt tttaactaac
     7741 ctaattgcat atttggcata aggtttaaac ttttaaggcc aactaaatgt caccttagtt
     7801 catacatgaa ctgtgtaaag gttagtcata cattgttcat ttttaaaact gcacatgggt
     7861 gtgtgcaaac cgttttgggt tacaaattta caagcaactt atataataat actaa
注：仅供参考，具体请咨询客服，以客服说明书为准