Human papillomavirus type 31 (HPV-31) complete genome
GenBank: J04353.1
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LOCUS       PPH31A                  7912 bp    DNA     circular VRL 18-MAR-1994
DEFINITION  Human papillomavirus type 31 (HPV-31) complete genome.
ACCESSION   J04353
VERSION     J04353.1
KEYWORDS    complete genome.
SOURCE      human papillomavirus 31
  ORGANISM  human papillomavirus 31
            Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
            Papovaviricetes; Zurhausenvirales; Papillomaviridae;
            Firstpapillomavirinae; Alphapapillomavirus.
REFERENCE   1  (bases 1 to 7912)
  AUTHORS   Goldsborough,M.D., DiSilvestre,D., Temple,G.F. and Lorincz,A.T.
  TITLE     Nucleotide sequence of human papillomavirus type 31: a cervical
            neoplasia-associated virus
  JOURNAL   Virology 171 (1), 306-311 (1989)
   PUBMED   2545036
COMMENT     Draft entry and computer-readable copy of sequence [1] kindly
            submitted by M.D.Goldsborough, 05-JUL-1989.
FEATURES             Location/Qualifiers
     source          1..7912
                     /organism="human papillomavirus 31"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:10585"
     regulatory      19..24
                     /regulatory_class="TATA_box"
     regulatory      69..74
                     /regulatory_class="TATA_box"
     gene            108..557
                     /gene="E6"
     CDS             108..557
                     /gene="E6"
                     /note="ORF E6 from bp 39 to 557"
                     /codon_start=1
                     /product="transforming protein"
                     /protein_id="AAA46950.1"
                     /translation="MFKNPAERPRKLHELSSALEIPYDELRLNCVYCKGQLTETEVLD
                     FAFTDLTIVYRDDTPHGVCTKCLRFYSKVSEFRWYRYSVYGTTLEKLTNKGICDLLIR
                     CITCQRPLCPEEKQRHLDKKKRFHNIGGRWTGRCIACWRRPRTETQV"
     misc_feature    228..236
                     /gene="E6"
                     /standard_name="Splice donor"
     misc_feature    403..414
                     /gene="E6"
                     /standard_name="Splice acceptor"
     gene            560..856
                     /gene="E7"
     CDS             560..856
                     /gene="E7"
                     /note="ORF E7 from bp 545 to 856"
                     /codon_start=1
                     /product="transforming protein"
                     /protein_id="AAA46951.1"
                     /translation="MRGETPTLQDYVLDLQPEATDLHCYEQLPDSSDEEDVIDSPAGQ
                     AEPDTSNYNIVTFCCQCKSTLRLCVQSTQVDIRILQELLMGSFGIVCPNCSTRL"
     gene            862..2751
                     /gene="E1"
     CDS             862..2751
                     /gene="E1"
                     /note="ORF E1 from bp 850 to bp 2751"
                     /codon_start=1
                     /product="replication protein"
                     /protein_id="AAA46952.1"
                     /translation="MADPAGTDGEGTGCNGWFYVEAVIDRQTGDNISEDENEDSSDTG
                     EDMVDFIDNCNVYNNQAEAETAQALFHAQEAEEHAEAVQVLKRKYVGSPLSDISSCVD
                     YNISPRLKAICIENNSKTAKRRLFELPDSGYGNTEVETQQMVQVEEQQTTLSCNGSDG
                     THSERENETPTRNILQVLKTSNGKAAMLGKFKELYGVSFMELIRPFQSNKSTCTDWCV
                     AAFGVTGTVAEGFKTLLQPYCLYCHLQSLACSWGMVMLMLVRFKCAKNRITIEKLLEK
                     LLCISTNCMLIQPPKLRSTAAALYWYRTGMSNISDVYGETPEWIERQTVLQHSFNDTT
                     FDLSQMVQWAYDNDVMDDSEIAYKYAQLADSDSNACAFLKSNSQAKIVKDCGTMCRHY
                     KRAEKRQMSMGQWIKSRCDKVSDEGDWRDIVKFLRYQQIEFVSFLSALKLFLKGVPKK
                     NCILIHGAPNTGKSYFGMSLISFLQGCIISYANSKSHFWLQPLADAKIGMLDDATTPC
                     WHYIDNYLRNALDGNPVSIDVKHKALMQLKCPPLLITSNINAGKDDRWPYLHSRLVVF
                     TFPNPFPFDKNGNPVYELSDKNWKSFFSRTWCRLNLHEEEDKENDGDSFSTFKCVSGQ
                     NIRTL"
     gene            2693..3811
                     /gene="E2"
     CDS             2693..3811
                     /gene="E2"
                     /note="ORF E2 from bp 2663 to 3811"
                     /codon_start=1
                     /product="regulatory protein"
                     /protein_id="AAA46953.1"
                     /translation="METLSQRLNVCQDKILEHYENDSKRLCDHIDYWKHIRLECVLMY
                     KAREMGIHSINHQVVPALSVSKAKALQAIELQMMLETLNNTEYKNEDWTMQQTSLELY
                     LTAPTGCLKKHGYTVEVQFDGDVHNTMHYTNWKFIYLCIDGQCTVVEGQVNCKGIYYV
                     HEGHITYFVNFTEEAKKYGTGKKWEVHAGGQVIVFPESVFSSDEISFAGIVTKLPTAN
                     NTTTSNSKTCALGTSEGVRRATTSTKRPRTEPEHRNTHHPNKLLRGDSVDSVNCGVIS
                     AAACTNQTRAVSCPATTPIIHLKGDANILKCLRYRLSKYKQLYEQVSSTWHWTCTDGK
                     HKNAIVTLTYISTSQRDDFLNTVKIPNTVSVSTGYMTI"
     gene            3270..3578
                     /gene="E4"
     CDS             <3270..3578
                     /gene="E4"
                     /note="ORF E4 from bp 3270 to 3578"
                     /codon_start=1
                     /protein_id="AAA46949.1"
                     /translation="LFFLNLYLAVTKYPLLGLLQSYQQPTTPPHRIPKPAPWAPVKVC
                     GGRRRLLSDQEQSQSTETPTTPTSCCEATPWTVSTVGLSVQLHAQTKQGLSVVLQLHL
                     "
     gene            3816..4070
                     /gene="E5"
     CDS             3816..4070
                     /gene="E5"
                     /note="ORF E5 from bp 3804 to 4070"
                     /codon_start=1
                     /protein_id="AAA46954.1"
                     /translation="MIELNISTVSIVLCFLLCFCVLLFVCLVIRPLVLSVSVYATLLL
                     LIVILWVIATSPLRCFCIYVVFIYIPLFVIHTHASFLSQQ"
     repeat_region   4099..4134
     regulatory      4138..4143
                     /regulatory_class="polyA_signal_sequence"
                     /note="putative"
     repeat_region   4143..4158
     gene            4171..5571
                     /gene="L2"
     CDS             4171..5571
                     /gene="L2"
                     /note="ORF L2 from bp 4060 to bp 5571"
                     /codon_start=1
                     /product="minor capsid protein"
                     /protein_id="AAA46955.1"
                     /translation="MRSKRSTKRTKRASATQLYQTCKAAGTCPSDVIPKIEHTTIADQ
                     ILRYGSMGVFFGGLGIGSGSGTGGRTGYVPLSTRPSTVSEASIPIRPPVSIDPVGPLD
                     PSIVSLVEESGIVDVGAPAPIPHPPTTSGFDIATTADTTPAILDVTSVSTHENPTFTD
                     PSVLQPPTPAETSGHLLLSSSSISTHNYEEIPMDTFIVSTNNENITSSTPIPGVRRPA
                     RLGLYSKATQQVKVIDPTFLSAPKQLITYENPAYETVNAEESLYFSNTSHNIAPDPDF
                     LDIIALHRPALTSRRNTVRYSRLGNKQTLRTRSGATIGARVHYYYDISSINPAGESIE
                     MQPLGASATTTSTLNDGLYDIYADTDFTVDTPATHNVSPSTAVQSTSAVSAYVPTNTT
                     VPLSTGFDIPIFSGPDVPIEHAPTQVFPFPLAPTTPQVSIFVDGGDFYLHPSYYMLKR
                     RRKRVSYFFTDVSVAA"
     gene            5552..7066
                     /gene="L1"
     CDS             5552..7066
                     /gene="L1"
                     /note="ORF L1 from bp 5516 to 7066"
                     /codon_start=1
                     /product="major capsid protein"
                     /protein_id="AAA46956.1"
                     /translation="MSLWRPSEATVYLPPVPVSKVVSTDEYVTRTNIYYHAGSARLLT
                     VGHPYYSIPKSDNPKKIVVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPETQRLVWA
                     CVGLEVGRGQPLGVGISGHPLLNKFDDTENSNRYAGGPGTDNRECISMDYKQTQLCLL
                     GCKPPIGEHWGKGSPCSNNAITPGDCPPLELKNSVIQDGDMVDTGFGAMDFTALQDTK
                     SNVPLDICNSICKYPDYLKMVAEPYGDTLFFYLRREQMFVRHFFNRSGTVGESVPTDL
                     YIKGSGSTATLANSTYFPTPSGSMVTSDAQIFNKPYWMQRAQGHNNGICWGNQLFVTV
                     VDTTRSTNMSVCAAIANSDTTFKSSNFKEYLRHGEEFDLQFIFQLCKITLSADIMTYI
                     HSMNPAILEDWNFGLTTPPSGSLEDTYRFVTSQAITCQKTAPQKPKEDPFKDYVFWEV
                     NLKEKFSADLDQFPLGRKFLLQAGYRARPKFKAGKRSAPSASTTTPAKRKKTKK"
     regulatory      7227..7231
                     /regulatory_class="polyA_signal_sequence"
                     /note="putative"
     repeat_region   7291..7302
     repeat_region   7314..7333
                     /note="putative"
     protein_bind    7406..7420
                     /standard_name="glucocorticoid responsive element"
                     /bound_moiety="hormone receptor"
     protein_bind    7477..7488
                     /bound_moiety="E2"
                     /function="gene transcription"
     regulatory      7542..7549
                     /regulatory_class="enhancer"
                     /standard_name="keratinocyte-dependant enhancer"
     protein_bind    7868..7879
                     /bound_moiety="E2"
                     /function="gene transcription"
ORIGIN      
        1 taataataat aatcttagta taaaaaagta gggagtgacc gaaagtggtg aaccgaaaac
       61 ggttggtata taaagcacat agtattttgt gcaaacctac agacgccatg ttcaaaaatc
      121 ctgcagaaag acctcggaaa ttgcatgaac taagctcggc attggaaata ccctacgatg
      181 aactaagatt gaattgtgtc tactgcaaag gtcagttaac agaaacagag gtattagatt
      241 ttgcatttac agatttaaca atagtatata gggacgacac accacacgga gtgtgtacaa
      301 aatgtttaag attttattca aaagtaagtg aatttagatg gtatagatat agtgtgtatg
      361 gaacaacatt agaaaaattg acaaacaaag gtatatgtga tttgttaatt aggtgtataa
      421 cgtgtcaaag accgttgtgt ccagaagaaa aacaaagaca tttggataaa aagaaacgat
      481 tccacaacat aggaggaagg tggacaggac gttgcatagc atgttggaga agacctcgta
      541 ctgaaaccca agtgtaaaca tgcgtggaga aacacctacg ttgcaagact atgtgttaga
      601 tttgcaacct gaggcaactg acctccactg ttatgagcaa ttacccgaca gctcagatga
      661 ggaggatgtc atagacagtc cagctggaca agcagaaccg gacacatcca attacaatat
      721 cgttaccttt tgttgtcagt gtaagtctac acttcgtttg tgtgtacaga gcacacaagt
      781 agatattcgc atattgcaag agctgttaat gggctcattt ggaatcgtgt gccccaactg
      841 ttctactaga ctgtaactac aatggctgat ccagcaggta cagatgggga ggggacggga
      901 tgcaatggtt ggttttatgt agaagcagta attgacagac agacagggga caacatttca
      961 gaggacgaaa atgaagacag tagtgatact ggggaggata tggttgactt tattgacaat
     1021 tgtaatgtat acaacaatca ggcagaagca gagacagcac aggcattgtt tcatgcacag
     1081 gaagcggagg aacatgcaga ggctgtgcag gttctaaaac gaaagtatgt aggtagtcct
     1141 ttaagtgata ttagtagttg tgtggattat aatattagtc cacggttaaa agctatatgc
     1201 atagaaaata acagtaaaac agcaaaacga agactctttg aacttccaga cagcgggtat
     1261 ggcaatactg aagtggaaac gcagcagatg gtacaggtag aggagcaaca aacaacatta
     1321 agttgtaatg gtagtgacgg gacacatagt gaacgagaga atgaaactcc aacacgtaat
     1381 atattgcaag tgttaaaaac tagcaatggt aaagctgcta tgttaggtaa atttaaagaa
     1441 ttatatggtg taagttttat ggaactaatt aggccatttc aaagcaataa aagcacatgt
     1501 actgattggt gtgtagctgc gtttggagtt acaggtacag ttgcagaagg atttaaaacc
     1561 ctattgcaac catattgttt gtattgccat ttacaaagtt tagcatgttc ctggggcatg
     1621 gttatgttaa tgcttgtgag atttaaatgt gcaaaaaata gaataacaat tgaaaaatta
     1681 ttagaaaaat tattgtgtat atctacaaat tgtatgttaa ttcagccacc caaattacgt
     1741 agcacagctg cagcattata ttggtacaga acaggaatgt caaacattag cgatgtatat
     1801 ggtgaaacac cagaatggat agaaagacaa acagtattac agcatagttt taatgacaca
     1861 acatttgatt tgtcccaaat ggtacaatgg gcatatgaca atgatgttat ggatgatagt
     1921 gaaattgcct ataaatatgc acaattagct gacagtgata gtaatgcatg tgcattttta
     1981 aaaagtaatt cgcaggcaaa aatagttaaa gattgtggaa caatgtgtag acattataaa
     2041 cgagcagaaa aacgacaaat gtccatggga cagtggatta aaagtagatg tgacaaagtt
     2101 agtgacgaag gtgactggag ggacatagta aagtttttaa gatatcaaca aatagaattt
     2161 gtgtcatttt tatctgcatt aaagctgttt ttaaaaggag tgccaaagaa aaactgtatt
     2221 ttaatacatg gtgcacctaa tacaggtaaa tcatattttg gaatgagcct tattagcttt
     2281 ttacaaggat gtataatatc atatgcaaat tcaaaaagtc atttttggtt acaaccactg
     2341 gctgatgcta aaataggcat gttagatgat gctacaacgc catgttggca ttatatagac
     2401 aattacctac gaaatgcact agatggcaac cctgtatcta tagatgtaaa gcataaagct
     2461 ttaatgcagt taaaatgtcc tcctttattg attacatcta atataaatgc aggtaaggat
     2521 gacagatggc catacctaca tagcagactg gtggttttta catttccaaa tccatttcca
     2581 tttgacaaaa acggaaatcc agtatatgaa ttaagtgata aaaactggaa atcctttttc
     2641 tcaaggacgt ggtgcagatt aaatttgcac gaggaagagg acaaagaaaa cgatggagac
     2701 tctttctcaa cgtttaaatg tgtgtcagga caaaatatta gaacattatg aaaatgatag
     2761 taaacgactt tgtgatcata tagactattg gaaacatatt cgacttgaat gtgtattaat
     2821 gtataaagca agagaaatgg gaatacacag tattaaccac caggtggtgc cagcgttgtc
     2881 agtatcaaag gccaaagcct tacaagctat tgaactacaa atgatgttgg aaacattaaa
     2941 taacactgaa tacaaaaatg aggactggac aatgcagcaa acaagtcttg aactgtattt
     3001 aactgcacct acagggtgtt taaaaaaaca tggatatact gtagaggtgc aatttgatgg
     3061 tgatgtacac aacaccatgc attatactaa ctggaaattt atatacctat gtatagatgg
     3121 ccaatgtact gttgtggaag ggcaagttaa ttgtaagggc atttattatg tacatgaagg
     3181 acatataaca tattttgtaa attttacaga agaggcaaaa aaatatggga ctggtaaaaa
     3241 atgggaagtg catgcgggtg gtcaggtaat tgtttttcct gaatctgtat ttagcagtga
     3301 cgaaatatcc tttgctggga ttgttacaaa gctaccaaca gccaacaaca ccaccacatc
     3361 gaattccaaa acctgcgcct tgggcaccag tgaaggtgtg cggcgggcga cgacgtctac
     3421 taagcgacca agaacagagc cagagcacag aaacacccac caccccaaca agttgttgcg
     3481 aggcgactcc gtggacagtg tcaactgtgg ggttatcagt gcagctgcat gcacaaacca
     3541 aacaagggct gtcagttgtc ctgcaactac acctataata cacttaaaag gtgatgcaaa
     3601 tatattaaaa tgtttaagat ataggctgtc aaaatataaa caattgtatg aacaagtgtc
     3661 atctacatgg cattggacat gtacagatgg aaaacataaa aatgctattg taaccttaac
     3721 atatataagt acatcacaaa gagacgattt tttaaatact gtaaaaatac ctaacacagt
     3781 atcagtgtca acaggatata tgactattta gcctaatgat tgaactaaat atttctacag
     3841 taagcattgt gctatgcttt ttgctttgct tttgtgtgct actatttgtg tgtcttgtca
     3901 tacgtccact tgtgctgtct gtgtcggtat atgcaacact actattatta attgtgattt
     3961 tatgggttat tgcaacctct ccattacgtt gtttttgtat atatgttgtg tttatatata
     4021 ttccattatt tgtaattcat acacatgcat cttttttaag tcaacagtaa cttttttact
     4081 tgtgtatact gttgtttgta ttggtattgg tattggtatt ggtattggta ttggtataat
     4141 aaactttttt actttttttt tattattacc atgcggtcca aacgctctac aaaacgcact
     4201 aaacgtgcgt ctgctacaca attatatcaa acatgtaaag cagcaggtac ttgtccatca
     4261 gacgttatac ctaaaataga acatactacc attgcagacc aaatattaag gtatggtagt
     4321 atgggtgttt tttttggtgg gttgggtatt gggtccggct ctggtactgg gggtcgcact
     4381 ggatatgtcc ctcttagtac acgtccttct acagtatctg aggcaagtat acctattaga
     4441 ccaccagtta gcattgaccc tgtaggtccc ttggacccct ctatagtaag tcttgttgaa
     4501 gaatctggaa ttgttgatgt tggtgcccct gctcctatac cacaccctcc tacaacatct
     4561 gggtttgaca ttgctacaac tgcagacaca acacctgcaa ttttagatgt aacaagtgtt
     4621 agcacacatg aaaatcctac ttttactgat ccatctgtat tgcagcctcc tacacctgca
     4681 gaaacatcag gtcatttact actttcatca tcatctatta gcacacataa ttatgaggaa
     4741 atacctatgg atacatttat tgtttctact aataatgaaa acataacaag tagcacaccc
     4801 attccagggg tgcgccgtcc tgcacgttta gggttatata gtaaggctac acaacaagta
     4861 aaagttattg atccaacgtt tcttagtgct ccaaaacagc taattacata tgaaaaccct
     4921 gcctatgaaa ctgtaaatgc tgaagaatct ttatactttt ccaatacatc gcataatata
     4981 gcccctgatc ccgactttct agatattata gcattacata ggcctgccct tacctcacgt
     5041 aggaacactg ttagatatag tagactaggt aataaacaaa ctttgcgcac tcgtagtggt
     5101 gctactattg gtgcaagggt gcattattat tatgatatta gtagtattaa tcctgcaggt
     5161 gaaagtattg aaatgcaacc tttaggggcg tctgcaacta ctacttctac tttaaatgat
     5221 ggcttatatg acatttatgc agacactgat tttactgtgg atacacctgc cacacataat
     5281 gtttcccctt ctactgctgt acagtccaca tctgctgtgt ctgcctatgt acctacaaat
     5341 accactgtgc cactaagtac aggttttgac attcccatat tttctgggcc tgatgtacct
     5401 atagagcatg cacctacaca ggttttccca tttcctttgg cccctacaac gccacaagtg
     5461 tctatttttg ttgatggggg tgatttttat ttgcacccta gttattatat gttaaaacgt
     5521 cgacgtaaac gtgtatcata tttttttaca gatgtctctg tggcggccta gcgaggctac
     5581 tgtctactta ccacctgtcc cagtgtctaa agttgtaagc acggatgaat atgtaacacg
     5641 aaccaacata tattatcacg caggcagtgc taggctgctt acagtaggcc atccatatta
     5701 ttccatacct aaatctgaca atcctaaaaa aatagttgta ccaaaggtgt caggattaca
     5761 atatagggta tttagggttc gtttaccaga tccaaacaaa tttggatttc ctgatacatc
     5821 tttttataat cctgaaactc aacgcttagt ttgggcctgt gttggtttag aggtaggtcg
     5881 cgggcagcca ttaggtgtag gtattagtgg tcatccatta ttaaataaat ttgatgacac
     5941 tgaaaactct aatagatatg ccggtggtcc tggcactgat aatagggaat gtatatcaat
     6001 ggattataaa caaacacaac tgtgtttact tggttgcaaa ccacctattg gagagcattg
     6061 gggtaaaggt agtccttgta gtaacaatgc tattacccct ggtgattgtc ctccattaga
     6121 attaaaaaat tcagttatac aagatgggga tatggttgat acaggctttg gagctatgga
     6181 ttttactgct ttacaagaca ctaaaagtaa tgttcctttg gacatttgta attctatttg
     6241 taaatatcca gattatctta aaatggttgc tgagccatat ggcgatacat tattttttta
     6301 tttacgtagg gaacaaatgt ttgtaaggca tttttttaat agatcaggca cggttggtga
     6361 atcggtccct actgacttat atattaaagg ctccggttca acagctactt tagctaacag
     6421 tacatacttt cctacaccta gcggctccat ggttacttca gatgcacaaa tttttaataa
     6481 accatattgg atgcaacgtg ctcagggaca caataatggt atttgttggg gcaatcagtt
     6541 atttgttact gtggtagata ccacacgtag taccaatatg tctgtttgtg ctgcaattgc
     6601 aaacagtgat actacattta aaagtagtaa ttttaaagag tatttaagac atggtgagga
     6661 atttgattta caatttatat ttcagttatg caaaataaca ttatctgcag acataatgac
     6721 atatattcac agtatgaatc ctgctatttt ggaagattgg aattttggat tgaccacacc
     6781 tccctcaggt tctttggagg atacctatag gtttgtcacc tcacaggcca ttacatgtca
     6841 aaaaactgcc ccccaaaagc ccaaggaaga tccatttaaa gattatgtat tttgggaggt
     6901 taatttaaaa gaaaagtttt ctgcagattt agatcagttt ccactgggtc gcaaattttt
     6961 attacaggca ggatataggg cacgtcctaa atttaaagca ggtaaacgta gtgcaccctc
     7021 agcatctacc actacaccag caaaacgtaa aaaaactaaa aagtaatgga tgtgtatgta
     7081 atacatgtgt ctgtatgtgt atgtgcttgt gctgtattgt atatgtgtgt gtttgtgtgt
     7141 tatatatggt atatgtatgt ttatgtatgc gtgtgtactt gtatatatgt atagtatgtt
     7201 atgtgtgtat gtatgctatg tatgttaata aatatgtgta tacctgtgtg tgttgtgtat
     7261 gttgtcctta tatacaccct attagtaaca tactattact attttataaa ctattgttcc
     7321 tacttgttcc tacttgttcc tgctcctccc aatagtcatg tacttatttc tgcctataat
     7381 ttaggtgtca cgccatagta aaagttgtac acccggtccg ttttttgcaa ctaaagctac
     7441 tccattttga ttttatgcag ccattttaaa tccctaaccg ttttcggttg cattgtttaa
     7501 acatgctagt acaactatgc tgatgcagta gttctgcggt ttttggtttc ctgaatacta
     7561 gtttttgcca acattctggc ttgtagtttc ctgcctaaca caccttgcca acatataatc
     7621 cagtccaact ttgcaattat actatgaatc atgtttgttt aaatacaact gtagttcaac
     7681 tatgtgtcat gcacatatat tatattatcc tacacacctt aaactgcttt taggcacata
     7741 ttttgtagat tatctatatc cttgattgca gtgctggctt ttgcacatgt ttaaactgcc
     7801 aaggttgtgt catgcattat aaataagttg tatgttactc atataattaa ttgcatatag
     7861 gtattacacc gttttcggtt acagttttac aagcaattgt tctttttata ct
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