Human papillomavirus type 33, complete genome
GenBank: M12732.1
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LOCUS       PPH33CG                 7909 bp    DNA     circular VRL 21-MAR-1994
DEFINITION  Human papillomavirus type 33, complete genome.
ACCESSION   M12732
VERSION     M12732.1
KEYWORDS    complete genome.
SOURCE      human papillomavirus 33
  ORGANISM  human papillomavirus 33
            Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
            Papovaviricetes; Zurhausenvirales; Papillomaviridae;
            Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 9.
REFERENCE   1  (bases 1 to 7909)
  AUTHORS   Cole,S.T. and Streeck,R.E.
  TITLE     Genome organization and nucleotide sequence of human papillomavirus
            type 33, which is associated with cervical cancer
  JOURNAL   J. Virol. 58 (3), 991-995 (1986)
   PUBMED   3009902
COMMENT     Original source text: Human papillomavirus type 33 DNA isolated
            from a human invasive cervical carcinoma, clone p15-5.
            Draft entry and computer-readable copy of the sequence were kindly
            provided by S.T.Cole, 04-AUG-1986.
FEATURES             Location/Qualifiers
     source          1..7909
                     /organism="human papillomavirus 33"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:10586"
     regulatory      7..10
                     /regulatory_class="TATA_box"
                     /note="putative"
     protein_bind    39..50
                     /note="putative"
                     /bound_moiety="E2"
                     /function="gene transcription"
     protein_bind    54..65
                     /note="putative"
                     /bound_moiety="E2"
                     /function="gene transcription"
     regulatory      71..75
                     /regulatory_class="TATA_box"
                     /note="putative"
     gene            109..558
                     /gene="E6"
     CDS             109..558
                     /gene="E6"
                     /note="E6 ORF from 76 to 558; putative"
                     /codon_start=1
                     /product="transforming protein"
                     /protein_id="AAA46958.1"
                     /translation="MFQDTEEKPRTLHDLCQALETTIHNIELQCVECKKPLQRSEVYD
                     FAFADLTVVYREGNPFGICKLCLRFLSKISEYRHYNYSVYGNTLEQTVKKPLNEILIR
                     CIICQRPLCPQEKKRHVDLNKRFHNISGRWAGRCAACWRSRRRETAL"
     gene            573..866
                     /gene="E7"
     CDS             573..866
                     /gene="E7"
                     /note="E7 ORF from bp 543 to 866; putative"
                     /codon_start=1
                     /product="transforming protein"
                     /protein_id="AAA46959.1"
                     /translation="MRGHKPTLKEYVLDLYPEPTDLYCYEQLSDSSDEDEGLDRPDGQ
                     AQPATADYYIVTCCHTCNTTVRLCVNSTASDLRTIQQLLMGTVNIVCPTCAQQ"
     gene            879..2813
                     /gene="E1"
     CDS             879..2813
                     /gene="E1"
                     /note="E1 ORF from bp 867 to 2813; putative"
                     /codon_start=1
                     /product="replication protein"
                     /protein_id="AAA46960.1"
                     /translation="MADPEGTNGAGMGCTGWFEVEAVIERRTGDNISEDEDETADDSG
                     TDLLEFIDDSMENSIQADTEAARALFNIQEGEDDLNAVCALKRKFAACSQSAAEDVVD
                     RAANPCRTSINKNKECTYRKRKIDELEDSGYGNTEVETQQMVQQVESQNGDTNLNDLE
                     SSGVGDDSEVSCETNVDSCENVTLQEISNVLHSSNTKANILYKFKEAYGISFMELVRP
                     FKSDKTSCTDWCITGYGISPSVAESLKVLIKQHSLYTHLQCLTCDRGIIILLLIRFRC
                     SKNRLTVAKLMSNLLSIPETCMVIEPPKLRSQTCALYWFRTAMSNISDVQGTTPEWID
                     RLTVLQHSFNDNIFDLSEMVQWAYDNELTDDSDIAYYYAQLADSNSNAAAFLKSNSQA
                     KIVKDCGIMCRHYKKAEKRKMSIGQWIQSRCEKTNDGGNWRPIVQLLRYQNIEFTAFL
                     GAFKKFLKGIPKKSCMLICGPANTGKSYFGMSLIQFLKGCVISCVNSKSHFWLQPLSD
                     AKIGMIDDVTPISWTYIDDYMRNALDGNEISIDVKHRALVQLKCPPLLLTSNTNAGTD
                     SRWPYLHSRLTVFEFKNPFPFDENGNPVYAINDENWKSFFSRTWCKLDLIEEEDKENH
                     GGNISTFKCSAGENTRSLRS"
     gene            2749..3810
                     /gene="E2"
     CDS             2749..3810
                     /gene="E2"
                     /note="E2 ORF from bp 2728 to 3810; putative"
                     /codon_start=1
                     /product="regulatory protein"
                     /protein_id="AAA46961.1"
                     /translation="MEEISARLNAVQEKILDLYEADKTDLPSQIEHWKLIRMECALLY
                     TAKQMGFSHLCHQVVPSLLASKTKAFQVIELQMALETLSKSQYSTSQWTLQQTSLEVW
                     LCEPPKCFKKQGETVTVQYDNDKKNTMDYTNWGEIYIIEEDTCTMVTGKVDYIGMYYI
                     HNCEKVYFKYFKEDAAKYSKTQMWEVHVGGQVIVCPTSISSNQISTTETADIQTDNDN
                     RPPQAAAKRRRPADTTDTAQPLTKLFCADPALDNRTARTATNCTNKQRTVCSSNVAPI
                     VHLKGESNSLKCLRYRLKPYKELYSSMSSTWHWTSDNKNSKNGIVTVTFVTEQQQQMF
                     LGTVKIPPTVQISTGFMTL"
     gene            3326..3577
                     /gene="E4"
     CDS             <3326..3577
                     /gene="E4"
                     /note="E4 ORF from bp 3326 to 3577; putative"
                     /codon_start=1
                     /protein_id="AAA46957.1"
                     /translation="LFVLRLYLATKYPLLKLLTYRQTTITDHHKQRPNDDDLQTPQTP
                     PSPLQSCSVQTPPWTIEQHVLQLTAQTSSGLCVVLTLHL"
     gene            3854..4081
                     /gene="E5"
     CDS             3854..4081
                     /gene="E5"
                     /note="E5 ORF from bp 3842 to 4081; putative"
                     /codon_start=1
                     /protein_id="AAA46962.1"
                     /translation="MIFVFVLCFILFLCLSLLLRPLILSISTYAWLLVLVLLLWVFVG
                     SPLKIFFCYLLFLYLPMMCINFHAQHMTQQE"
     gene            4210..5613
                     /gene="L2"
     CDS             4210..5613
                     /gene="L2"
                     /note="L2 ORF from bp 4198 to 5613; putative"
                     /codon_start=1
                     /product="minor capsid protein"
                     /protein_id="AAA46963.1"
                     /translation="MRHKRSTRRKRASATQLYQTCKATGTCPPDVIPKVEGSTIADQI
                     LKYGSLGVFFGGLGIGTGSGSGGRTGYVPIGTDPPTAAIPLQPIRPPVTVDTVGPLDS
                     SIVSLIEETSFIEAGAPAPSIPTPSGFDVTTSADTTPAIINVSSVGESSIQTISTHLN
                     PTFTEPSVLHPPAPAEASGHFIFSSPTVSTQSYENIPMDTFVVSTDSSNVTSSTPIPG
                     SRPVARLGLYSRNTQQVKVVDPAFLTSPHKLITYDNPAFESFDPEDTLQFQHSDISPA
                     PDPDFLDIIALHRPAITSRRHTVRFSRVGQKATLKTRSGKQIGARIHYYQDLSPIVPL
                     DHTVPNEQYELQPLHDTSTSSYSINDGLYDVYADDVDNVHTPMQHSYSTFATTRTSNV
                     SIPLNTGFDTPVMSGPDIPSPLFPTSSPFVPISPFFPFDTIVVDGADFVLHPSYFILR
                     RRRKRFPYFFTDVRVAA"
     gene            5594..7093
                     /gene="L1"
     CDS             5594..7093
                     /gene="L1"
                     /note="L1 ORF from bp 5516 to 7093; putative"
                     /codon_start=1
                     /product="major capsid protein"
                     /protein_id="AAA46964.1"
                     /translation="MSVWRPSEATVYLPPVPVSKVVSTDEYVSRTSIYYYAGSSRLLA
                     VGHPYFSIKNPTNAKKLLVPKVSGLQYRVFRVRLPDPNKFGFPDTSFYNPDTQRLVWA
                     CVGLEIGRGQPLGVGISGHPLLNKFDDTETGNKYPGQPGADNRECLSMDYKQTQLCLL
                     GCKPPTGEHWGKGVACTNAAPANDCPPLELINTIIEDGDMVDTGFGCMDFKTLQANKS
                     DVPIDICGSTCKYPDYLKMTSEPYGDSLFFFLRREQMFVRHFFNRAGTLGEAVPDDLY
                     IKGSGTTASIQSSAFFPTPSGSMVTSESQLFNKPYWLQRAQGHNNGICWGNQVFVTVV
                     DTTRSTNMTLCTQVTSDSTYKNENFKEYIRHVEEYDLQFVFQLCKVTLTAEVMTYIHA
                     MNPDILEDWQFGLTPPPSASLQDTYRFVTSQAITCQKTVPPKEKEDPLGKYTFWEVDL
                     KEKFSADLDQFPLGRKFLLQAGLKAKPKLKRAAPTSTRTSSAKRKKVKK"
     repeat_region   7098..7323
                     /note="putative"
     protein_bind    7502..7513
                     /note="putative"
                     /bound_moiety="E2"
                     /function="gene transcription"
     repeat_region   7517..7574
     misc_structure  7520..7530
                     /standard_name="Z DNA structure"
                     /note="putative"
     misc_structure  7599..7609
                     /standard_name="Z DNA structure"
                     /note="putative"
     regulatory      7891..7894
                     /regulatory_class="TATA_box"
                     /note="putative"
     regulatory      7901..7904
                     /regulatory_class="TATA_box"
                     /note="putative"
ORIGIN      
        1 gtaaactata atgccaagtt ttaaaaaagt agggtgtaac cgaaagcggt tcaaccgaaa
       61 acggtgcata tataaagcaa acattttgca gtaaggtact gcacgactat gtttcaagac
      121 actgaggaaa aaccacgaac attgcatgat ttgtgccaag cattggagac aactatacac
      181 aacattgaac tacagtgcgt ggaatgcaaa aaacctttgc aacgatctga ggtatatgat
      241 tttgcatttg cagatttaac agttgtatat agagagggaa atccatttgg aatatgtaaa
      301 ctgtgtttgc ggttcttatc taaaattagt gaatatagac attataatta ttctgtatat
      361 ggaaatacat tagaacaaac agttaaaaaa cctttaaatg aaatattaat taggtgtatt
      421 atatgtcaaa gacctttgtg tcctcaagaa aaaaaacgac atgtggattt aaacaaacga
      481 tttcataata tttcgggtcg ttgggcaggg cgctgtgcgg cgtgttggag gtcccgacgt
      541 agagaaactg cactgtgacg tgtaaaaacg ccatgagagg acacaagcca acgttaaagg
      601 aatatgtttt agatttatat cctgaaccaa ctgacctata ctgctatgag caattaagtg
      661 acagctcaga tgaggatgaa ggcttggacc ggccagatgg acaagcacaa ccagccacag
      721 ctgattacta cattgtaacc tgttgtcaca cttgtaacac cacagttcgt ttatgtgtca
      781 acagtacagc aagtgaccta cgaaccatac agcaactact tatgggcaca gtgaatattg
      841 tgtgccctac ctgtgcacaa caataaacat catctacaat ggccgatcct gaaggtacaa
      901 atggggctgg gatggggtgt actggttggt ttgaggtaga agcagtcata gagagaagaa
      961 caggagataa tatttcagaa gatgaggatg aaacagcaga tgacagtggc acggatttac
     1021 tagagtttat agatgattct atggaaaata gtatacaggc agacacagag gcagcccggg
     1081 cattgtttaa tatacaggaa ggggaggatg atttaaatgc tgtgtgtgca ctaaaacgaa
     1141 agtttgccgc atgttcacaa agtgctgcgg aggacgttgt tgatcgtgct gcaaacccgt
     1201 gtagaacgtc tattaataaa aataaagaat gcacatacag aaaacgaaaa atagatgagc
     1261 tagaagacag cggatatggc aatactgaag tggaaactca gcagatggta caacaggtag
     1321 aaagtcaaaa tggcgacaca aacttaaatg acttagaatc tagtggggtg ggggatgatt
     1381 cagaagtaag ctgtgagaca aatgtagata gctgtgaaaa tgttacgttg caggaaatta
     1441 gtaatgttct acatagtagt aatacaaaag caaatatatt atataaattt aaagaggcct
     1501 atggaataag ttttatggaa ttagtaagac catttaaaag tgataaaaca agctgtacag
     1561 attggtgtat aacaggatat ggaattagtc catcagtagc agaaagttta aaagtattaa
     1621 ttaaacagca tagtttgtat actcatttac aatgtttaac ttgcgataga ggaataataa
     1681 tattattgtt aattagattt aggtgtagca aaaacaggtt aacagtagca aaactaatga
     1741 gtaatttatt atcaatacct gaaacatgta tggttataga gccaccaaaa ttacggagcc
     1801 aaacatgtgc attgtattgg tttagaacag caatgtcaaa cattagtgat gtacaaggta
     1861 caacacctga atggatagat agactaactg ttttacaaca tagctttaat gataatatat
     1921 ttgatttaag tgaaatggta cagtgggcat atgataacga gttaacggac gatagtgaca
     1981 ttgcatatta ttatgcacaa cttgcagatt caaatagtaa tgctgctgca tttttaaaaa
     2041 gtaactcaca agcaaaaata gtaaaggact gtggaataat gtgtagacat tataaaaaag
     2101 cagaaaaacg taaaatgtca ataggacaat ggatacaaag tagatgtgaa aaaacaaatg
     2161 atggaggaaa ttggagacca atagtacagt tgttaagata tcaaaacatt gaatttacag
     2221 catttttagg tgcatttaaa aagtttttaa aaggtatacc aaaaaaaagc tgtatgctaa
     2281 tttgtggacc agcaaataca ggaaagtcat attttggaat gagtttaata cagtttttaa
     2341 aagggtgtgt tatatcatgt gtaaattcta aaagtcactt ttggttgcag ccattatcag
     2401 atgcaaaaat aggaatgata gatgatgtaa cgccaataag ttggacatat atagatgatt
     2461 acatgagaaa tgcgttagat ggaaatgaaa tttcaataga tgtgaaacat agggcattag
     2521 tgcaattaaa atgtccacca ctgcttctta cctcaaatac aaatgcaggc acagactcta
     2581 gatggccata tttacatagt agattaacag tatttgaatt taaaaatcca ttcccatttg
     2641 atgaaaatgg taacccagtg tatgcaataa atgatgaaaa ttggaaatcc tttttctcaa
     2701 ggacgtggtg caaattagat ttaatagagg aagaggacaa ggaaaaccat ggaggaaata
     2761 tcagcacgtt taaatgcagt gcaggagaaa atactagatc tttacgaagc tgataaaact
     2821 gatttaccat cacaaattga acattggaaa ctgatacgca tggagtgtgc tttattgtat
     2881 acagccaaac aaatgggatt ttcacattta tgccaccagg tggtgccttc tttgttagca
     2941 tcaaagacca aagcatttca agtaattgaa ctacaaatgg cattagagac attaagtaaa
     3001 tcacagtata gtacaagcca atggacattg caacaaacaa gcttagaggt gtggctttgt
     3061 gaaccaccaa aatgttttaa aaaacaagga gaaacagtaa ctgtgcaata tgacaatgac
     3121 aaaaaaaata caatggatta tacaaactgg ggtgaaatat atattataga ggaagataca
     3181 tgtactatgg ttacagggaa agtagattat ataggtatgt attatataca taactgtgaa
     3241 aaggtatatt ttaaatattt taaagaggat gctgcaaagt attctaaaac acaaatgtgg
     3301 gaagtacatg tgggtggtca ggtaattgtt tgtcctacgt ctatatctag caaccaaata
     3361 tccactactg aaactgctga catacagaca gacaacgata accgaccacc acaagcagcg
     3421 gccaaacgac gacgacctgc agacaccaca gacaccgccc agccccttac aaagctgttc
     3481 tgtgcagacc ccgccttgga caatagaaca gcacgtactg caactaactg cacaaacaag
     3541 cagcggactg tgtgtagttc taacgttgca cctatagtgc atttaaaagg tgaatcaaat
     3601 agtttaaaat gtttaagata cagattaaaa ccttataaag agttgtatag ttctatgtca
     3661 tccacctggc attggaccag tgacaacaaa aatagtaaaa atggaattgt aactgtaaca
     3721 tttgtaactg aacagcaaca acaaatgttt ttaggtaccg taaaaatacc acctactgtg
     3781 caaataagta ctggatttat gacattataa gtgtacatca caagccaata tgtgctgcta
     3841 attgtatata accatgatat ttgtttttgt attatgtttt atattgtttt tatgcttatc
     3901 cttattatta cgtcctttaa tactttccat ttctacctat gcttggttgc tggtgttggt
     3961 attgctgctt tgggtgtttg tgggatctcc tttaaaaatt tttttttgct atttgttgtt
     4021 tttatattta ccaatgatgt gtattaattt tcatgcacag catatgacac aacaagagta
     4081 atgtatatac atgtatatat tgtttgtata tatgtgcaca tggtggtgtt ttaacattgt
     4141 tgttgttatt ttagtttttt tttttttgta ttactaataa atacctttat attttagcag
     4201 tgtattatta tgagacacaa acgatctaca aggcgcaagc gtgcatctgc aacacaacta
     4261 taccaaacat gcaaggccac aggcacctgc ccacccgatg ttattcctaa agtggaagga
     4321 agtaccatag cagatcaaat tcttaaatat ggcagtttag gggttttttt tggtggttta
     4381 ggtattggca caggctctgg ttcaggtgga aggactggct atgtacctat tggtactgac
     4441 ccacctacag ctgcaatccc cttgcagcct atacgtcctc cggttactgt agacactgtt
     4501 ggacctttag actcgtctat agtgtcatta atagaagaaa caagttttat agaggcaggt
     4561 gcaccagccc catctattcc tacaccatca ggttttgatg ttactacatc tgcagatact
     4621 acacctgcaa ttattaatgt ttcatctgtt ggggagtcat ctattcaaac tatttctaca
     4681 catttaaatc ccacatttac tgaaccatct gtactacacc ctccagcgcc tgcagaagcc
     4741 tctggacatt ttatattttc ttcccctact gttagcacac aaagttatga aaacatacca
     4801 atggatacct ttgttgtttc cacagacagt agtaatgtaa catcaagcac gcccattcca
     4861 gggtctcgcc ctgtggcacg ccttggttta tatagtcgca atacccaaca ggttaaggtt
     4921 gttgaccctg cttttttaac atcgcctcat aaacttataa catatgataa tcctgcattt
     4981 gaaagctttg accctgaaga cacattacaa tttcaacata gtgatatatc acctgctcct
     5041 gatcctgact ttctagatat tattgcatta cataggcctg ctattacatc tcgtagacat
     5101 actgtgcgtt ttagtagagt aggtcaaaaa gccacactta aaactcgcag tggtaaacaa
     5161 attggagcta gaatacatta ttatcaggat ttaagtccta ttgtgccttt agaccacacc
     5221 gtgccaaatg aacaatatga attacagcct ttacatgata cttctacatc gtcttatagt
     5281 attaatgatg gtttgtatga tgtttatgct gacgatgtgg ataatgtaca caccccaatg
     5341 caacactcat acagtacgtt tgcaacaaca cgtaccagca atgtgtctat acctttaaat
     5401 acaggatttg atactcctgt tatgtctggc cctgatatac cttccccttt atttcccaca
     5461 tctagcccat ttgttcctat ttcgcctttt tttccttttg acaccattgt tgtagacggt
     5521 gctgactttg ttttacatcc tagttatttt attttacgtc gcaggcgtaa acgttttcca
     5581 tattttttta cagatgtccg tgtggcggcc tagtgaggcc acagtgtacc tgcctcctgt
     5641 acctgtatct aaagttgtca gcactgatga atatgtgtct cgcacaagca tttattatta
     5701 tgctggtagt tccagacttc ttgctgttgg ccatccatat ttttctatta aaaatcctac
     5761 taacgctaaa aaattattgg tacccaaagt atcaggcttg caatataggg tttttagggt
     5821 ccgtttacca gatcctaata aatttggatt tcctgacacc tccttttata accctgatac
     5881 acaacgatta gtatgggcat gtgtaggcct tgaaataggt agagggcagc cattaggcgt
     5941 tggcataagt ggtcatcctt tattaaacaa atttgatgac actgaaaccg gtaacaagta
     6001 tcctggacaa ccgggtgctg ataataggga atgtttatcc atggattata aacaaacaca
     6061 gttatgttta cttggatgta agcctccaac aggggaacat tggggtaaag gtgttgcttg
     6121 tactaatgca gcacctgcca atgattgtcc acctttagaa cttataaata ctattattga
     6181 ggatggtgat atggtggaca caggatttgg ttgcatggat tttaaaacat tgcaggctaa
     6241 taaaagtgat gttcctattg atatttgtgg cagtacatgc aaatatccag attatttaaa
     6301 aatgactagt gagccttatg gtgatagttt atttttcttt cttcgacgtg aacaaatgtt
     6361 tgtaagacac ttttttaata gggctggtac attaggagag gctgttcccg atgacctgta
     6421 cattaaaggt tcaggaacta ctgcctctat tcaaagcagt gctttttttc ccactcctag
     6481 tggatcaatg gttacttccg aatctcagtt atttaataag ccatattggc tacaacgtgc
     6541 acaaggtcat aataatggta tttgttgggg caatcaggta tttgttactg tggtagatac
     6601 cactcgcagt actaatatga ctttatgcac acaagtaact agtgacagta catataaaaa
     6661 tgaaaatttt aaagaatata taagacatgt tgaagaatat gatctacagt ttgtttttca
     6721 actatgcaaa gttaccttaa ctgcagaagt tatgacatat attcatgcta tgaatccaga
     6781 tattttagaa gattggcaat ttggtttaac acctcctcca tctgctagtt tacaggatac
     6841 ctataggttt gttacctctc aggctattac gtgtcaaaaa acagtacctc caaaggaaaa
     6901 ggaagacccc ttaggtaaat atacattttg ggaagtggat ttaaaggaaa aattttcagc
     6961 agatttagat cagtttcctt tgggacgcaa gtttttatta caggcaggtc ttaaagcaaa
     7021 acctaaactt aaacgtgcag cccccacatc cacccgcaca tcgtctgcaa aacgcaaaaa
     7081 ggttaaaaaa taacactttg tgtaattgtg ttatgttgtt gttttgttct gtctatgtac
     7141 tttgtgttgt tgtgttgtgt tgttgtttgt tttttgtgta tgtgttacaa tgtatgttat
     7201 gttgtatgtt actgtgtttg ttttatgtgt acttgtttgt gtgcatgttc tatgtacttg
     7261 tcagtttcct gtttgtgtat atgttaataa aacattgtgt gtatttgtta aactatttgt
     7321 atgtatgtta tgtatatggg tgtacctata tgagtaagga gttgtattgc ttgccctacc
     7381 ctgcattgca atgtacctac ctttatttcc ctatatttgt agtacctaca tgtttagtat
     7441 tgctttacct tttgacatac tagtgtccat attgtacaat ttcctccatt ttgtatgcct
     7501 aaccgttttc ggttacttgg catacatacc ctatgacatt ggcagaacag ttaatccttt
     7561 tctttcctgc actgtgtttg tctgtacttg ctgcattggc atacataccc tatgacattg
     7621 gcagaacagt taatcctttt ctttcctgca ctgtgtttgt ctgtacttgc tgcattgact
     7681 catatataca tgcagtgcaa ttgcaaaata cttaattgta ctaatagttt acacatgctt
     7741 ttaggcacat atttttactt tactttcaaa ccttaagtgc agttttggct tacacaattg
     7801 ctttgtatgc caaactatgc cttgtaaaag tgagtcacta cctgtttatt accaggtgtg
     7861 gactaaccgt tttaggtcat attggtcatt tataatcttt tatataata
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