Human papillomavirus ORFs
GenBank: M62849.1
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LOCUS       PPHT39                  7833 bp    DNA     circular VRL 26-JAN-2001
DEFINITION  Human papillomavirus ORFs.
ACCESSION   M62849 M38185
VERSION     M62849.1
KEYWORDS    intraepithelial neoplasia; invasive carcinoma; papillomavirus.
SOURCE      human papillomavirus 39
  ORGANISM  human papillomavirus 39
            Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
            Papovaviricetes; Zurhausenvirales; Papillomaviridae;
            Firstpapillomavirinae; Alphapapillomavirus.
REFERENCE   1  (bases 1 to 7833)
  AUTHORS   Volpers,C. and Streeck,R.E.
  TITLE     Genome organization and nucleotide sequence of human papillomavirus
            type 39
  JOURNAL   Virology 181 (1), 419-423 (1991)
   PUBMED   1847266
FEATURES             Location/Qualifiers
     source          1..7833
                     /organism="human papillomavirus 39"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:10588"
     5'UTR           join(7161..7833,1..106)
                     /standard_name="LCR"
     regulatory      33..42
                     /regulatory_class="promoter"
                     /note="putative"
     protein_bind    43..54
                     /note="putative"
                     /bound_moiety="E2"
                     /function="gene transcription"
     protein_bind    59..70
                     /note="putative"
                     /bound_moiety="E2"
                     /function="gene transcription"
     regulatory      74..80
                     /regulatory_class="TATA_box"
                     /note="putative"
     gene            107..583
                     /gene="E6"
     CDS             107..583
                     /gene="E6"
                     /note="putative"
                     /codon_start=1
                     /product="transforming protein"
                     /protein_id="AAA47050.1"
                     /translation="MARFHNPAERPYKLPDLCTTLDTTLQDITIACVYCRRPLQQTEV
                     YEFAFSDLYVVYRDGEPLAACQSCIKFYAKIRELRYYSDSVYATTLENITNTKLYNLL
                     IRCMCCLKPLCPAEKLRHLNSKRRFHKIAGSYTGQCRRCWTTKREDRRLTRRETQV"
     gene            592..921
                     /gene="E7"
     CDS             592..921
                     /gene="E7"
                     /note="putative"
                     /codon_start=1
                     /product="transforming protein"
                     /protein_id="AAA47051.1"
                     /translation="MRGPKPTLQEIVLDLCPYNEIQPVDLVCHEQLGESEDEIDEPDH
                     AVNHQHQLLARRDEPQRHTIQCSCCKCNNTLQLVVEASRDTLRQLQQLFMDSLGFVCP
                     WCATANQ"
     gene            928..2871
                     /gene="E1"
     CDS             928..2871
                     /gene="E1"
                     /note="putative"
                     /codon_start=1
                     /product="replication protein"
                     /protein_id="AAA47052.1"
                     /translation="MANREGTDGDGSGCNGWFLVQAIVDKQTGDTVSEDEDENATDTG
                     SDLADFIDDSTDICVQAERETAQVLLHMQEAQRDAQAVRALKRKYTDSSGDTRPYGKK
                     VGRNTRGTLQEISLNVSSTQATQTVYSVPDSGYGNMEVETAEVEEVTVATNTNGDAEG
                     EHGGSVREECSSVDSAIDSENQDPKSPTAQIKLLLQSNNKKAAMLTQFKETYGLSFTD
                     LVRTFKSDKTTCTDWVAAIFGVHPTIAEGFKTLINKYALYTHIQSLDTKQGVLILMLI
                     RYTCGKNRVTVGKGLSTLLHVPESCMLLEPPKLRSPVAALYWYRTGISNISVVTGDTP
                     EWIQRLTVIQHGIDDSVFDLSDMVQWAFDNEYTDESDIAFNYAMLADCNSNAAAFLKS
                     NCQAKYVKDCATMCKHYKRAQKRQMSMSQWIKFRCSKCDEGGDWRPIVQFLRYQGIEF
                     ISFLCALKEFLKGTPKKNCIVIYGPANTGKSHFCMSLMHFLQGTVISYVNSTSHFWLE
                     PLADAKLAMLDDATGTCWSYFDNYMRNALDGYAISLDRKYKSLLQMKCPPLLITSNTN
                     PVEDDRWPYLRSRLTVFKFPNAFPFDQNRNPVYTINDKNWKCFFEKTWCRLDLQQDED
                     EGDNDENTFTTFKCVTGQNTRIL"
     gene            2798..3910
                     /gene="E2"
     CDS             2798..3910
                     /gene="E2"
                     /note="putative"
                     /codon_start=1
                     /product="regulatory protein"
                     /protein_id="AAA47053.1"
                     /translation="MKETMMKTLSQRLNVLQDKILEYYEQDSKSIYDQINYWKCVRME
                     NAIFYAARERGMHTIDHQVVPTINISKCKAYQAIELQMALESVAQTEYNTEEWTLKDT
                     SNELWHTQPKQCFKKQGTTVEVWYDGDKCNAMNYVLWGAIYYKNNIDIWCKTEGCVDY
                     WGIYYMNEHLKVYYEVFIQDAERYGTSGKWEVHYNGNIIHCPDSMCSTSDGSVPTTEL
                     TTELSNTTATHSTATTPCTQKTIPPPSRKRPRQCAVTEPTEPDGVSLDHLNNPLHSNS
                     TGHNTRRYLSCGNTTPIIHLKGDKNGLKCLRYRLQKYDTLFENISCTWHWIRGKGTKN
                     AGILTVTYATESQRQKFLDTVKIPSSVHVSLGYMTL"
     gene            3393..3677
                     /gene="E4"
     CDS             <3393..3677
                     /gene="E4"
                     /note="putative"
                     /codon_start=1
                     /product="E4 ORF"
                     /protein_id="AAA47049.1"
                     /translation="FIVLTLCAVPVTDRYPLLNLLPNYQTPPRPIPPQQPHAPKKQSR
                     RRLESDLDSVQSQSPLSPTECPWTILTTHSTVTVQATTQDGTSVVVTLRL"
     gene            3958..4176
                     /gene="E5"
     CDS             3958..4176
                     /gene="E5"
                     /note="putative"
                     /codon_start=1
                     /product="E5 ORF"
                     /protein_id="AAA47054.1"
                     /translation="MILLVFLVWFGVCIYICCNVPLLPSVHVCAYVWIIVFVFILIRT
                     TPLEVFFVYLLFFVLPMWLLHRLAMDMI"
     regulatory      4243..4248
                     /regulatory_class="polyA_signal_sequence"
     gene            4250..5662
                     /gene="L2"
     CDS             4250..5662
                     /gene="L2"
                     /note="putative"
                     /codon_start=1
                     /product="minor capsid protein"
                     /protein_id="AAA47055.1"
                     /translation="MVSHRAARRKRASATDLYRTCKQSGTCPPDVVDKVEGTTLADKI
                     LQWTSLGIFLGGLGIGTGTGTGGRTGYIPLGGRPNTVVDVSPARPPVVIEPVGPSEPS
                     IVQLVEDSSVITSGTPVPTFTGTSGFEITSSSTTTPAVLDITPSSGSVQITSTSYTNP
                     AFTDPSLIEVPQTGETSGNIFVSTPTSGTHGYEEIPMEVFATHGTGTEPISSTPTPGI
                     SRVAGPRLYSRAHQQVRVSNFDFVTHPSSFVTFDNPAFEPVDTTLTYEAADIAPDPDF
                     LDIVRLHRPALTSRKGTVRFSRLGKKATMVTRRGTQIGAQVHYYHDISSIAPAESIEL
                     QPLVHAEPSDASDALFDIYADVDNNTYLDTAFNNTRDSGTTYNTGSLPSVASSASTKY
                     ANTTIPFSTSWNMPVNTGPDIALPSTTPQLPLVPSGPIDTTYAITIQGSNYYLLPLLY
                     FFLKKRKRIPYFFSDGYVAV"
     gene            5643..7160
                     /gene="L1"
     CDS             5643..7160
                     /gene="L1"
                     /note="L1 ORF from bp 5610 to 7160; putative"
                     /codon_start=1
                     /product="major capsid protein"
                     /protein_id="AAA47056.1"
                     /translation="MAMWRSSDSMVYLPPPSVAKVVNTDDYVTRTGIYYYAGSSRLLT
                     VGHPYFKVGMNGGRKQDIPKVSAYQYRVFRVTLPDPNKFSIPDASLYNPETQRLVWAC
                     VGVEVGRGQPLGVGISGHPLYNRQDDTENSPFSSTTNKDSRDNVSVDYKQTQLCIIGC
                     VPAIGEHWGKGKACKPNNVSTGDCPPLELVNTPIEDGDMIDTGYGAMDFGALQETKSE
                     VPLDICQSICKYPDYLQMSADVYGDSMFFCLRREQLFARHFWNRGGMVGDAIPAQLYI
                     KGTDIRANPGSSVYCPSPSGSMVTSDSQLFNKPYWLHKAQGHNNGICWHNQLFLTVVD
                     TTRSTNFTLSTSIESSIPSTYDPSKFKEYTRHVEEYDLQFIFQLCTVTLTTDVMSYIH
                     TMNSSILDNWNFAVAPPPSASLVDTYRYLQSAAITCQKDAPAPEKKDPYDGLKFWNVD
                     LREKFSLELDQFPLGRKFLLQARVRRRPTIGPRKRPAASTSSSSATKHKRKRVSK"
     protein_bind    6367..6381
                     /gene="L1"
                     /standard_name="glucocorticoid responsive element"
                     /note="putative"
                     /bound_moiety="hormone receptor"
     regulatory      7261..7266
                     /regulatory_class="polyA_signal_sequence"
     protein_bind    7425..7439
                     /standard_name="glucocorticoid responsive element"
                     /note="putative"
                     /bound_moiety="hormone receptor"
     protein_bind    7456..7467
                     /note="putative"
                     /bound_moiety="E2"
                     /function="gene transcription"
     protein_bind    7798..7809
                     /note="putative"
                     /bound_moiety="E2"
                     /function="gene transcription"
ORIGIN      
        1 cttataacat tttataagta tcttgtttaa aaaaagggag taaccgaaaa cggtcaggac
       61 cgaaatcggt ggatataaaa cgcagtcaca gtttctgtcc ataccgatgg cgcgatttca
      121 caatcctgca gaacggccat acaaattgcc agacctgtgc acaacgctgg acaccacctt
      181 gcaggacatt acaatagcct gtgtctattg cagacgacca ctacagcaaa ccgaggtata
      241 tgaatttgca tttagtgatt tatatgtagt atatagggac ggggaaccac tagctgcatg
      301 ccaatcatgt ataaaatttt atgctaaaat acgggagcta cgatattact cggactcggt
      361 gtatgcaact acattagaaa atataactaa tacaaagtta tataatttat taataaggtg
      421 catgtgttgt ctgaaaccgc tgtgtccagc agaaaaatta agacacctaa atagcaaacg
      481 aagatttcat aaaatagcag gaagctatac aggacagtgt cgacggtgct ggaccacaaa
      541 acgggaggac cgcagactaa cacgaagaga aacccaagta taacatcaga tatgcgtgga
      601 ccaaagccca ccttgcagga aattgtatta gatttatgtc cttacaatga aatacagccg
      661 gttgaccttg tatgtcacga gcaattagga gagtcagagg atgaaataga tgaacccgac
      721 catgcagtta atcaccaaca tcaactacta gccagacggg atgaaccaca gcgtcacaca
      781 atacagtgtt cgtgttgtaa gtgtaacaac acactgcagc tggtagtaga agcctcacgg
      841 gatactctgc gacaactaca gcagctgttt atggactcac taggatttgt gtgtccgtgg
      901 tgtgcaactg caaaccagta acctgctatg gccaatcgtg aaggtacaga cggggatggg
      961 tcgggatgta acggatggtt tctagtacag gcaatagtag ataaacaaac aggcgacaca
     1021 gtgtcggagg atgaggatga aaatgcaaca gatacaggtt cagacctggc agactttatt
     1081 gatgattcca cagatatttg tgtacaggca gagcgtgaga cagcacaggt acttttacat
     1141 atgcaagagg cccaaaggga tgcacaagca gtgcgtgcct taaaacgaaa gtatacagac
     1201 agcagtggcg acactagacc gtatggaaaa aaagtaggca ggaataccag gggaacacta
     1261 caggaaattt cattaaatgt aagcagtacg caggcaacac aaacggtgta ttccgtgcca
     1321 gacagcggat atggcaatat ggaagtggaa acagctgaag tggaggaggt aactgtagca
     1381 actaatacaa atggggatgc tgaaggggaa catggcggca gtgtacggga ggagtgcagt
     1441 agtgtggata gtgctataga tagtgaaaac caggatccca aatctccaac tgcacaaatt
     1501 aaattattgt tacaatccaa taacaaaaag gctgcaatgc taacacaatt taaagaaaca
     1561 tatggactat cctttactga cctggtacgt acgtttaaaa gtgataaaac aacatgtaca
     1621 gactgggtgg cagccatatt tggagtacat ccaactattg cagaaggatt taaaacatta
     1681 atcaacaaat atgccttata tacacatata caaagcttag acacaaaaca aggagtacta
     1741 attttaatgc taataagata tacatgtgga aaaaataggg ttactgtagg aaagggatta
     1801 agtacattgt tacatgttcc agaaagttgt atgcttctgg agcctcctaa actgcgcagc
     1861 cctgtagcag cactatattg gtatcgcaca ggtatatcca atattagtgt ggtaacaggg
     1921 gatacgccag aatggataca acgattaact gttatacaac atggaataga tgatagtgta
     1981 tttgacctat cggacatggt acaatgggca tttgacaatg aatatactga tgaaagtgac
     2041 atagcattta attatgcaat gttagcagat tgtaacagta atgctgcagc ctttttaaaa
     2101 agtaactgcc aggcaaaata tgtaaaagat tgtgcaacaa tgtgtaaaca ttacaagcga
     2161 gcacaaaaaa ggcaaatgtc catgtctcaa tggataaaat ttaggtgtag taaatgtgat
     2221 gaaggcgggg actggagacc catagtacaa ttcttaagat atcaaggaat agaatttata
     2281 tcctttttat gtgcattaaa ggaattttta aagggtactc ccaaaaaaaa ctgtatagtt
     2341 atatatggac ctgcgaatac aggaaagtca catttttgta tgagccttat gcatttttta
     2401 cagggcacag ttatttcata tgtaaactcc accagccact tttggctaga accacttgca
     2461 gatgcaaaac tagcaatgtt agatgatgca accggtacct gctggtcata tttcgataat
     2521 tatatgagaa atgcattaga tgggtatgca ataagtttag ataggaaata taaaagttta
     2581 ctacaaatga aatgtccacc attattaata acctccaata ccaatcctgt ggaagacgat
     2641 aggtggccat atttacgtag taggctaaca gtgtttaaat ttcctaatgc atttccattt
     2701 gaccaaaaca ggaatccagt gtacacaatc aatgataaaa actggaaatg tttttttgaa
     2761 aagacttggt gcagattaga cttgcagcag gacgaggatg aaggagacaa tgatgaaaac
     2821 actttcacaa cgtttaaatg tgttacagga caaaatacta gaatactatg aacaagacag
     2881 taaatcaata tatgatcaaa ttaattattg gaaatgtgtg cgaatggaaa atgcaatatt
     2941 ttatgcagca cgagaacgtg gcatgcatac tattgaccac caggtggtgc caaccataaa
     3001 catttcaaaa tgtaaagcat atcaagctat tgaactgcag atggcactag aaagtgttgc
     3061 acaaactgaa tacaatacag aggagtggac attaaaagac actagtaatg aactgtggca
     3121 tacacagcca aaacaatgtt ttaaaaaaca aggaactaca gtggaggtgt ggtatgatgg
     3181 ggacaaatgt aatgctatga actatgtatt atggggtgct atatattata aaaataatat
     3241 agacatatgg tgtaaaacag aagggtgtgt ggactattgg ggtatatatt atatgaacga
     3301 gcacctaaaa gtatactatg aagtgtttat tcaagatgcg gaaaggtatg ggactagtgg
     3361 caaatgggaa gtgcattata atggcaacat aattcattgt cctgactcta tgtgcagtac
     3421 cagtgacgga tcggtaccca ctactgaact tactaccgaa ttatcaaaca ccaccgcgac
     3481 ccattccacc gcaacaaccc catgcaccca aaaaacaatc ccgccgccgt ctcgaaagcg
     3541 acctcgacag tgtgcagtca cagagcccac tgagcccgac ggagtgtccc tggaccatct
     3601 taacaaccca ctccacagta acagtacagg ccacaacaca agacggtacc tcagttgtgg
     3661 taacactacg cctataatac atttaaaagg tgacaaaaat ggtttaaaat gtttaagata
     3721 tagactacaa aaatatgaca cattgtttga aaatatttca tgtacctggc attggatacg
     3781 gggtaaggga accaaaaacg ctggcatatt aactgttaca tatgccacag agtcacaacg
     3841 ccaaaaattt ttggacactg ttaaaatacc ttctagtgta catgtttcat tgggttacat
     3901 gacattgtaa agtatactat ggatattgtg tatgtatatt gtatacatac tacatagatg
     3961 atattattgg tatttttggt gtggtttggt gtgtgtatat atatatgttg caatgtcccg
     4021 cttttgccgt ctgtgcatgt gtgtgcgtat gtgtggataa ttgtgtttgt gtttattctt
     4081 atacgtacca caccattgga ggtgtttttt gtatatttac tattttttgt attgcccatg
     4141 tggttgttgc atagactggc aatggatatg atatagtact gtatatgtat gtgcattgtg
     4201 cataactact gtacatagct ttttatattt ttttttgtta ctaataaaca tggtttccca
     4261 ccgtgctgcc aggcgtaagc gtgcatctgc aactgaccta tatagaacct gtaaacaatc
     4321 gggtacctgt ccaccagacg ttgttgataa agttgagggt actacacttg ctgacaaaat
     4381 tttacagtgg actagtttag gtatattttt gggtgggtta ggcataggca caggtactgg
     4441 tactggggga cgcacaggat atatacccct ggggggtagg cctaatactg ttgtagatgt
     4501 gtctcctgca cgtccacctg tagttattga acctgttggt ccttctgagc catctattgt
     4561 gcaattggtg gaggactcaa gtgttataac ctctggaaca ccagtaccaa catttacagg
     4621 cacctctgga tttgaaatta cttcttcttc tactactacg cctgcggtat tggatattac
     4681 accctcctct gggtctgtac aaataacctc tactagttat actaaccctg cctttacgga
     4741 tccttcctta attgaggttc cccaaacagg tgaaacctcg ggtaatatat ttgtcagtac
     4801 ccctacatca ggtacacatg gctatgagga aatacctatg gaagtgtttg ccacacatgg
     4861 cacaggtacc gaacctatta gcagcacacc tacacctgga atcagtcgtg tggcaggacc
     4921 acgtttatat agtagagcac atcagcaggt tcgtgttagt aattttgatt ttgtaactca
     4981 cccttcatca tttgtaacat ttgataatcc tgcttttgag cctgttgata ctacattaac
     5041 atatgaagct gctgacatag ctccagatcc ggattttctg gacattgttc gtttacatag
     5101 gcctgcctta acctcgcgta aaggaacagt aaggtttagt aggcttggca aaaaggctac
     5161 catggttacc cggcgtggca cacaaattgg agcgcaagta cattattacc atgacattag
     5221 tagtattgct cctgctgaaa gcattgaatt acagccccta gttcacgctg agccctctga
     5281 tgcttcagat gcattatttg atatatatgc tgatgtggac aataacacat atttagatac
     5341 tgcatttaat aatacaaggg attcgggcac tacatataac acaggctcac taccttctgt
     5401 ggcttcttca gcatctacta aatatgccaa tacaactatt ccttttagta cctcatggaa
     5461 tatgcctgta aatactggtc ctgatattgc tttaccaagt actactccac agttgccatt
     5521 ggtgccttct ggaccaatag acacaacata tgcaataacc attcagggtt ccaattatta
     5581 tttgttgcca ttattgtatt ttttcctaaa aaaacgtaaa cgtattccct attttttttc
     5641 agatggctat gtggcggtct agtgacagca tggtgtattt gcctccacct tctgtggcga
     5701 aggttgtcaa tactgatgat tatgttacac gcacaggcat atattattat gctggcagct
     5761 ctagattatt aacagtagga catccatatt ttaaagtggg tatgaatggt ggtcgcaagc
     5821 aggacattcc aaaggtgtct gcatatcaat atagggtatt tcgcgtgaca ttgcccgatc
     5881 ctaataaatt cagtattcca gatgcatcct tatataatcc agaaacacaa cgtttagtat
     5941 gggcttgtgt aggggtggag gtgggcaggg gccagccatt gggtgttggt attagtggac
     6001 acccattata taatagacag gatgatactg aaaactcacc attttcatca accaccaata
     6061 aggacagtag ggataatgtg tctgtggatt ataaacagac acagttgtgc attataggct
     6121 gtgttcccgc cattggggag cactggggta agggaaaggc atgcaagccc aataatgtat
     6181 ctacggggga ctgtcctcct ttggaactag taaacacccc tattgaggat ggtgatatga
     6241 ttgatactgg ctatggagct atggactttg gtgcattgca ggaaaccaaa agtgaggtgc
     6301 ctttagatat ttgtcaatcc atttgtaaat atcctgatta tttgcaaatg tctgcagatg
     6361 tgtatgggga cagtatgttc ttctgtttac gtagggaaca actgtttgca agacattttt
     6421 ggaatcgtgg tggtatggtg ggtgacgcca ttcctgccca attgtatatt aagggcacag
     6481 atatacgtgc aaaccccggt agttctgtat actgcccctc tcccagcggt tccatggtaa
     6541 cctctgattc ccagttattt aataagcctt attggctaca taaggcccag ggccacaaca
     6601 atggtatatg ttggcataat caattatttc ttactgttgt ggacactacc cgtagtacca
     6661 actttacatt atctacctct atagagtctt ccataccttc tacatatgat ccttctaagt
     6721 ttaaggaata taccaggcac gtggaggagt atgatttaca atttatattt caactgtgta
     6781 ctgtcacatt aacaactgat gttatgtctt atattcacac tatgaattcc tctatattgg
     6841 acaattggaa ttttgctgta gctcctccac catctgccag tttggtagac acttacagat
     6901 acctacagtc tgcagccatt acatgtcaaa aggatgctcc agcacctgaa aagaaagatc
     6961 catatgacgg tctaaagttt tggaatgttg acttaaggga aaagtttagt ttggaacttg
     7021 atcaattccc tttgggacgt aaatttttgt tgcaggccag ggtccgcagg cgccctacta
     7081 taggtccccg aaagcggcct gctgcatcca cttcctcgtc ctcagctact aaacacaaac
     7141 gtaaacgtgt gtctaaataa tgcatgtgta tgccttgtta tgtgtgtgta tgttgtttgt
     7201 ttccttatgt gttgagtgta tatgtgtatg tttgtaggta tgtgtgtata tgtttttgtt
     7261 aataaagtat gtatgacagt ttcatgtgtg attgcacacc ctgtgactaa cagtgtattt
     7321 gttttacata taataggtct gcaacatttc atacataatc tatatgccct accctaaggt
     7381 gtgtttacta cctaatatgt aatttttaca ttgttgtatg cgtttctaca ttttatactt
     7441 cgccattttg tggcgaccga agtcggtcgt gggttgagca ttttttttaa actagtggaa
     7501 accacctttc tcagcaaaaa catgtcttta ccttaggttc accctgcata gttggcactg
     7561 gtaacagttt tactggcgcg ccttattact catcatcctg tccaggtgca ctgcaacaat
     7621 actttggcaa catccatatc tccaccctat gtaataaaac tgcttttagg catatatttt
     7681 agctgttttt acttgcttaa ttaaatagtt ggcctgtata actacttttt gattcaggaa
     7741 tgtgtcttac agtataagtt atacaagtga ctaatgtagc acacaatagt ttatgcaacc
     7801 gaaataggtt gggcatacat acctatactt tta
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