Human papillomavirus type 45 genomic DNA
GenBank: X74479.1
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LOCUS       X74479                  7858 bp    DNA     linear   VRL 18-APR-2005
DEFINITION  Human papillomavirus type 45 genomic DNA.
ACCESSION   X74479
VERSION     X74479.1
KEYWORDS    E1 gene; E2 gene; E4 gene; E6 gene; E7 gene; early protein; L1
            gene; L2 gene; late protein.
SOURCE      human papillomavirus 45
  ORGANISM  human papillomavirus 45
            Viruses; Monodnaviria; Shotokuvirae; Cossaviricota;
            Papovaviricetes; Zurhausenvirales; Papillomaviridae;
            Firstpapillomavirinae; Alphapapillomavirus.
REFERENCE   1  (bases 1 to 7858)
  AUTHORS   Delius,H. and Hofmann,B.
  TITLE     Primer-directed sequencing of human papillomavirus types
  JOURNAL   Curr. Top. Microbiol. Immunol. 186, 13-31 (1994)
   PUBMED   8205838
REFERENCE   2  (bases 1 to 7858)
  AUTHORS   Delius,H.
  TITLE     Direct Submission
  JOURNAL   Submitted (06-AUG-1993) H. Delius, Deutsches
            Krebsforschungszentrum, Abteilung ATV, Im Neuenheimer Feld 506, W
            6900 Heidelberg, FRG
FEATURES             Location/Qualifiers
     source          1..7858
                     /organism="human papillomavirus 45"
                     /mol_type="genomic DNA"
                     /db_xref="taxon:10593"
                     /clone="insert in HindIII site of pGEM-1"
     gene            102..578
                     /gene="E6"
     CDS             102..578
                     /gene="E6"
                     /codon_start=1
                     /product="early protein"
                     /protein_id="CAA52573.1"
                     /db_xref="GOA:P21735"
                     /db_xref="InterPro:IPR001334"
                     /db_xref="UniProtKB/Swiss-Prot:P21735"
                     /translation="MARFDDPKQRPYKLPDLCTELNTSLQDVSIACVYCKATLERTEV
                     YQFAFKDLCIVYRDCIAYAACHKCIDFYSRIRELRYYSNSVYGETLEKITNTELYNLL
                     IRCLRCQKPLNPAEKRRHLKDKRRFHSIAGQYRGQCNTCCDQARQERLRRRRETQV"
     gene            587..907
                     /gene="E7"
     CDS             587..907
                     /gene="E7"
                     /codon_start=1
                     /product="early protein"
                     /protein_id="CAA52574.1"
                     /db_xref="GOA:P21736"
                     /db_xref="InterPro:IPR000148"
                     /db_xref="PDB:2EWL"
                     /db_xref="PDB:2F8B"
                     /db_xref="UniProtKB/Swiss-Prot:P21736"
                     /translation="MHGPRETLQEIVLHLEPQNELDPVDLLCYEQLSESEEENDEADG
                     VSHAQLPARRAEPQRHKILCVCCKCDGRIELTVESSAEDLRTLQQLFLSTLSFVCPWC
                     ATNQ"
     gene            914..2845
                     /gene="E1"
     CDS             914..2845
                     /gene="E1"
                     /codon_start=1
                     /product="early protein"
                     /protein_id="CAA52575.1"
                     /db_xref="GOA:P36728"
                     /db_xref="InterPro:IPR001177"
                     /db_xref="InterPro:IPR014000"
                     /db_xref="InterPro:IPR014015"
                     /db_xref="InterPro:IPR016393"
                     /db_xref="UniProtKB/Swiss-Prot:P36728"
                     /translation="MADPEGTDGEGTGCNGWFFVETIVEKKTGDVISDDEDETATDTG
                     SDMVDFIDTQLSICEQAEQETAQALFHAQEVQNDAQVLHLLKRKFAGGSKENSPLGEQ
                     LSVDTDLSPRLQEISLNSGHKKAKRRLFTISDSGYGCSEVEAAETQVTVNTNAENGGS
                     VHSTQSSGGDSSDNAENVDPHCSITELKELLQASNKKAAMLAVFKDIYGLSFTDLVRN
                     FKSDKTTCTDWVMAIFGVNPTVAEGFKTLIKPATLYAHIQCLDCKWGVLILALLRYKC
                     GKNRLTVAKGLSTLLHVPETCMLIEPPKLRSSVAALYWYRTGISNISEVSGDTPEWIQ
                     RLTIIQHGIDDSNFDLSDMVQWAFDNDLTDESDMAFQYAQLADCNSNAAAFLKSNCQA
                     KYLKDCAVMCRHYKRAQKRQMNMSQWIKYRCSKIDEGGDWRPIVQFLRYQGVEFISFL
                     RALKEFLKGTPKKNCILLYGPANTGKSYFGMSFIHFLQGAIISFVNSNSHFWLEPLAD
                     TKVAMLDDATHTCWTYFDNYMRNALDGNPISIDRKHKPLLQLKCPPILLTSNIDPAKD
                     NKWPYLESRVTVFTFPHAFPFDKNGNPVYEINDKNWKCFFERTWSRLDLHEDDEDADT
                     EGIPFGTFKCVTGQNTRPL"
     gene            2769..3875
                     /gene="E2"
     CDS             2769..3875
                     /gene="E2"
                     /codon_start=1
                     /product="early protein"
                     /protein_id="CAA52576.1"
                     /db_xref="GOA:P36794"
                     /db_xref="InterPro:IPR000427"
                     /db_xref="InterPro:IPR001866"
                     /db_xref="InterPro:IPR009021"
                     /db_xref="InterPro:IPR012677"
                     /db_xref="UniProtKB/Swiss-Prot:P36794"
                     /translation="MKMQTPKESLSERLSALQDKILDHYENDSKDINSQISYWQLIRL
                     ENAILFTAREHGITKLNHQVVPPINISKSKAHKAIELQMALKGLAQSKYNNEEWTLQD
                     TCEELWNTEPSQCFKKGGKTVHVYFDGNKDNCMNYVVWDSIYYITETGIWDKTAACVS
                     YWGVYYIKDGDTTYYVQFKSECEKYGNSNTWEVQYGGNVIDCNDSMCSTSDDTVSATQ
                     IVRQLQHASTSTPKTASVGTPKPHIQTPATKRPRQCGLTEQHHGRVNTHVHNPLLCSS
                     TSNNKRRKVCSGNTTPIIHLKGDKNSLKCLRYRLRKYADHYSEISSTWHWTGCNKNTG
                     ILTVTYNSEVQRNTFLDVVTIPNSVQISVGYMTI"
     gene            4236..5627
                     /gene="L2"
     CDS             4236..5627
                     /gene="L2"
                     /codon_start=1
                     /product="late protein"
                     /protein_id="CAA52577.1"
                     /db_xref="GOA:P36761"
                     /db_xref="InterPro:IPR000784"
                     /db_xref="UniProtKB/Swiss-Prot:P36761"
                     /translation="MVSHRAARRKRASATDLYRTCKQSGTCPPDVINKVEGTTLADKI
                     LQWSSLGIFLGGLGIGTGSGSGGRTGYVPLGGRSNTVVDVGPTRPPVVIEPVGPTDPS
                     IVTLVEDSSVVASGAPVPTFTGTSGFEITSSGTTTPAVLDITPTVDSVSISSTSFTNP
                     AFSDPSIIEVPQTGEVSGNIFVGTPTSGSHGYEEIPLQTFASSGSGTEPISSTPLPTV
                     RRVRGPRLYSRANQQVRVSTSQFLTHPSSLVTFDNPAYEPLDTTLSFEPTSNVPDSDF
                     MDIIRLHRPALSSRRGTVRFSRLGQRATMFTRSGKQIGGRVHFYHDISPIAATEEIEL
                     QPLISATNDSDLFDVYADFPPPASTTPSTIHKSFTYPKYSLTMPSTAASSYSNVTVPL
                     TSAWDVPIYTGPDIILPSHTPMWPSTSPTNASTTTYIGIHGTQYYLWPWYYYFPKKRK
                     RIPYFFADGFVAA"
     gene            5530..7149
                     /gene="L1"
     CDS             5530..7149
                     /gene="L1"
                     /codon_start=1
                     /product="late protein"
                     /protein_id="CAA52578.1"
                     /db_xref="GOA:P36741"
                     /db_xref="InterPro:IPR002210"
                     /db_xref="InterPro:IPR011222"
                     /db_xref="UniProtKB/Swiss-Prot:P36741"
                     /translation="MAHNIIYGHGIIIFLKNVNVFPIFLQMALWRPSDSTVYLPPPSV
                     ARVVSTDDYVSRTSIFYHAGSSRLLTVGNPYFRVVPNGAGNKQAVPKVSAYQYRVFRV
                     ALPDPNKFGLPDSTIYNPETQRLVWACVGMEIGRGQPLGIGLSGHPFYNKLDDTESAH
                     AATAVITQDVRDNVSVDYKQTQLCILGCVPAIGEHWAKGTLCKPAQLQPGDCPPLELK
                     NTIIEDGDMVDTGYGAMDFSTLQDTKCEVPLDICQSICKYPDYLQMSADPYGDSMFFC
                     LRREQLFARHFWNRAGVMGDTVPTDLYIKGTSANMRETPGSCVYSPSPSGSIITSDSQ
                     LFNKPYWLHKAQGHNNGICWHNQLFVTVVDTTRSTNLTLCASTQNPVPSTYDPTKFKQ
                     YSRHVEEYDLQFIFQLCTITLTAEVMSYIHSMNSSILENWNFGVPPPPTTSLVDTYRF
                     VQSVAVTCQKDTTPPEKQDPYDKLKFWTVDLKEKFSSDLDQYPLGRKFLVQAGLRRRP
                     TIGPRKRPAASTSTASTASRPAKRVRIRSKK"
ORIGIN      
        1 aatactttta acaattatac tacataaaaa agggtgtaac cgaaaacggt tgcaaccaaa
       61 aacggtgcat ataaaagctt tgtggaaaag tgcattacag gatggcgcgc tttgacgatc
      121 caaagcaacg accctacaag ctaccagatt tgtgcacaga attgaataca tcactacaag
      181 acgtatctat tgcctgtgta tattgcaaag caacattgga acgcacagag gtatatcaat
      241 ttgcttttaa agatttatgt atagtgtata gagactgtat agcatatgct gcatgccata
      301 aatgtataga cttttattcc agaattagag aattaagata ttattcaaac tctgtatatg
      361 gagagacact ggaaaaaata actaatacag agttgtataa tttgttaata aggtgcctgc
      421 ggtgccagaa accattgaac ccagcagaaa aacgtagaca ccttaaggac aaacgaagat
      481 ttcacagcat agctggacag taccgagggc agtgtaatac atgttgtgac caggcacggc
      541 aagaaagact tcgcagacgt agggaaacac aagtatagca ataagtatgc atggaccccg
      601 ggaaacactg caagaaattg tattgcattt ggaacctcag aatgaattag atcctgttga
      661 cctgttgtgt tacgagcaat taagcgagtc agaggaggaa aacgatgaag cagatggagt
      721 tagtcatgca caactaccag cccgacgagc cgaaccacag cgtcacaaaa ttttgtgtgt
      781 atgttgtaag tgtgacggca gaattgagct tacagtagag agctcggcag aggaccttag
      841 aacactacag cagctgtttt tgagcacctt gtcctttgtg tgtccgtggt gtgcaactaa
      901 ccaataatct acaatggcgg atccagaagg taccgacggg gagggaacgg ggtgtaatgg
      961 ctggttcttt gtagaaacaa ttgtagagaa aaaaacaggg gatgtaatat cagatgatga
     1021 ggatgaaact gcaacagata cagggtcgga tatggtagat tttattgaca cacaattatc
     1081 catttgtgaa caggcagagc aagagacagc acaggcattg ttccatgcgc aggaagttca
     1141 gaatgatgca caggtgttgc atcttttaaa acgaaagttt gcaggaggca gcaaggaaaa
     1201 cagtccatta ggggagcagc taagtgtgga tacggatcta agtccacggt tacaagaaat
     1261 ttcattaaat agtgggcaca aaaaagcaaa acgacggttg tttacaatat cagatagtgg
     1321 ctatggctgt tctgaagtgg aagctgcaga gactcaggta actgtaaaca ctaatgcgga
     1381 aaatggcggc agtgtacata gtacacaaag tagtggtggg gatagtagtg acaatgcaga
     1441 aaatgtagat ccgcattgca gtattacaga actaaaggag ctattacaag caagtaacaa
     1501 aaaggctgca atgctggcag tatttaaaga catatatggg ctgtcattta cggatttggt
     1561 tagaaatttt aaaagtgata aaacaacatg tacagattgg gtaatggcta tatttggagt
     1621 taatccaacg gtagcagaag gctttaaaac attaattaaa ccagcaacgt tatacgccca
     1681 tatccaatgt ttagattgta aatggggagt attaatatta gctttattaa gatataaatg
     1741 tggcaaaaat agactaactg ttgcaaaagg cttaagcaca ttgttgcacg tacctgaaac
     1801 atgtatgtta attgaaccac caaaattgcg aagtagtgtt gcagcattat actggtatag
     1861 aacaggtata tccaatatta gtgaagtaag tggagacaca cctgagtgga tacaaagact
     1921 gacaattatt caacatggta ttgacgatag taattttgat ttgtcagaca tggtgcaatg
     1981 ggcatttgat aatgacctta cagatgaaag tgatatggca tttcaatatg cccaattagc
     2041 agactgcaac agtaatgcag ctgcattttt aaaaagtaac tgccaagcca aatatttaaa
     2101 agattgtgct gtaatgtgta gacattataa aagagcacaa aaacgccaaa tgaatatgtc
     2161 tcaatggatt aaatatagat gttccaaaat agatgaaggt ggggattgga gacccatagt
     2221 acaattccta agatatcagg gagtagaatt tattagcttt ttaagggcac taaaggaatt
     2281 tcttaaagga acaccaaaaa aaaattgtat actgttatat ggacctgcaa atacaggaaa
     2341 atcgtatttt ggaatgagtt ttatacattt cctacaaggt gcaataatat catttgtaaa
     2401 ttcaaacagc catttttggt tagaaccgtt agcagatact aaggtagcca tgttggatga
     2461 tgccacacac acgtgttgga catattttga taattatatg agaaatgcat tagatggtaa
     2521 tcctataagt atagacagaa agcataaacc attattacag ctaaaatgtc ctccaatcct
     2581 attaacatcc aatattgatc cagcaaaaga taataaatgg ccatatttag aaagtagggt
     2641 gacggtattt acatttccac atgcatttcc atttgataaa aatggtaatc cagtatatga
     2701 aataaatgat aaaaattgga aatgtttttt tgaaaggaca tggtccagat tagatttgca
     2761 cgaggacgat gaagatgcag acaccgaagg aatccctttc ggaacgttta agtgcgttac
     2821 aggacaaaat actagaccac tatgaaaatg acagtaaaga cataaacagc caaataagtt
     2881 attggcaact tatacgtttg gaaaatgcaa tactatttac agcaagggaa catggtatta
     2941 ccaaactaaa ccaccaggtg gtgcctccta ttaacatttc aaaaagcaaa gcacataaag
     3001 ctattgaact gcaaatggcc ttaaagggcc ttgcacaaag caagtataac aatgaggaat
     3061 ggacactgca agatacatgc gaggaactat ggaatacaga accgtcgcag tgttttaaaa
     3121 aaggcggtaa aaccgtgcac gtatactttg atggcaacaa ggacaactgt atgaactatg
     3181 tagtatggga cagtatatat tatataactg agacagggat atgggacaaa acagcagcat
     3241 gtgttagcta ttggggtgta tattatataa aagatggaga taccacatat tatgtacaat
     3301 ttaaaagcga atgtgagaaa tatggaaata gtaatacgtg ggaagtacaa tatgggggca
     3361 atgtaattga ttgtaatgac tctatgtgca gtaccagtga cgacacggta tccgctactc
     3421 agattgttag acagctacaa cacgcctcca cgtcgacccc caaaaccgca tccgtgggca
     3481 ccccaaaacc ccacatccag acgccggcta ctaagcgacc tagacagtgt ggactcacag
     3541 agcagcacca cggacgtgtc aacacccacg tgcacaaccc gctcctgtgt tcaagtacaa
     3601 gtaacaacaa aagaaggaaa gtgtgtagtg gtaacactac gcctataata cacttaaaag
     3661 gtgacaaaaa cagtttgaaa tgtttaagat ataggctacg caaatatgca gaccattact
     3721 cagaaatatc ctccacctgg cattggacag gttgtaataa aaacactggt atattaactg
     3781 taacatataa tagtgaggta caaagaaata cctttttgga tgtagttact attcctaaca
     3841 gtgtacaaat ctcggtggga tacatgacta tatgaatctg tatattgtat acagtatgta
     3901 acattactat gctatcttta gtgtttttat tgtgcttttc tgtgtgcctt tatgtgtgct
     3961 gcaatgtccc gcttgtgcag tctgtctatg tgtgtgcttt tgcttggttg ttggtgtttc
     4021 tttttatagt tgttattaca tccccattaa cagcatttgc tgtatacatt tgttgctatt
     4081 tactacctat gtttgtatta catatgcatg ctttacacac catacaataa ttactataat
     4141 gtacagtaca gtgtaacata cctgtgatgt gcatgttgtt gtatttttgt atttttgtat
     4201 ttttgtattt ttgtatttta tatgtttaat aaaccatggt atcccaccgt gcagcacgtc
     4261 gcaagcgggc ctctgcaact gacttatata gaacatgtaa gcaatccggt acgtgccccc
     4321 ctgatgttat taacaaagtg gaaggcacaa ccttagctga taaaatttta cagtggtcta
     4381 gccttgggat atttttgggt ggccttggca ttggtaccgg cagtggttct ggaggccgta
     4441 cgggctatgt acccttaggg ggcaggtcta atactgttgt ggatgttggc cccactaggc
     4501 cacctgtggt tattgaacct gtagggccta ctgatccatc tattgttacg ttggtagagg
     4561 attccagtgt tgttgcctct ggtgctccgg ttcccacatt taccggaacc tctgggtttg
     4621 aaattacgtc ttctggtact accacaccag ctgtgttgga catcacacct accgtggact
     4681 ctgtttctat ttcgtcaact agttttacaa atcctgcatt ttctgatccc tctattattg
     4741 aggtgcccca aacaggggag gtatcaggta atatatttgt tggtacacca acatcgggca
     4801 gccatggata tgaggaaata cctttacaaa catttgcatc ttctgggtca ggtacggaac
     4861 ccattagtag tacccccctc cctactgtgc ggcgggtacg gggtccccgc ctgtatagta
     4921 gggctaatca acaggtccgt gtgtccacct cacagttttt aacacatccc tcatcgttgg
     4981 ttacatttga taatccagct tatgagcccc tggacaccac actatccttt gagcctacca
     5041 gtaatgttcc tgattccgat tttatggata ttattcgttt gcataggcca gcattatcct
     5101 ctagacgtgg cactgttaga tttagtagat tgggtcaaag ggcaaccatg tttacacgta
     5161 gtggtaaaca aatagggggt agggtacatt tttaccatga tataagcccc attgctgcta
     5221 cagaggaaat tgaattgcag cctttaatta gtgctacaaa tgatagtgac ctgtttgatg
     5281 tatatgcaga cttcccacct cctgcgtcca ctacacctag cactatacac aaatcattta
     5341 catatccaaa gtattccttg accatgcctt ctactgctgc atcctcttac agtaatgtta
     5401 cagtaccatt aacatctgca tgggatgtac ctatatatac tggcccggac attatattgc
     5461 catcccatac tcctatgtgg cctagtacat ctcctaccaa tgcttccacc accacctata
     5521 taggtattca tggcacacaa tattatttat ggccatggta ttattatttt cctaaaaaac
     5581 gtaaacgtat tccctatttt tttgcagatg gctttgtggc ggcctagtga cagtacggta
     5641 tatcttccac caccttctgt ggccagagtt gtcagcactg atgattatgt gtctcgcaca
     5701 agcatatttt atcatgcagg cagttcccga ttattaactg taggcaatcc atattttagg
     5761 gttgtaccta atggtgcagg taataaacag gctgttccta aggtatccgc atatcagtat
     5821 agggtgttta gagtagcttt acccgatcct aataaatttg gattacctga ttctactata
     5881 tataatcctg aaacacaacg tttggtttgg gcatgtgtag gtatggaaat tggtcgtggg
     5941 cagcctttag gtattggcct aagtggccat ccattttata ataaattgga tgatacagaa
     6001 agtgctcatg cagctacagc tgttattacg caggatgtta gggataatgt gtcagttgat
     6061 tataagcaaa cacagctgtg tattttaggt tgtgtacctg ctattggtga gcactgggcc
     6121 aagggcacac tttgtaaacc tgcacaattg caacctggtg actgtcctcc tttggaactt
     6181 aaaaacacca ttattgagga tggtgatatg gtggatacag gttatggggc aatggatttt
     6241 agtacattgc aggatacaaa gtgcgaggtt ccattagaca tttgtcaatc catctgtaaa
     6301 tatccagatt atttgcaaat gtctgctgat ccctatgggg attctatgtt tttttgccta
     6361 cgccgtgaac aactgtttgc aagacatttt tggaataggg caggtgttat gggtgacaca
     6421 gtacctacgg acctatatat taaaggcact agcgctaata tgcgtgaaac ccctggcagt
     6481 tgtgtgtatt ccccttctcc cagtggctct attattactt ctgattctca attatttaat
     6541 aagccatatt ggttacataa ggcccagggc cataacaatg gtatttgttg gcataatcag
     6601 ttgtttgtta ctgtagtgga cactacccgc agtactaatt taacattatg tgcctctaca
     6661 caaaatcctg tgccaagtac atatgaccct actaagttta agcagtatag tagacatgtg
     6721 gaggaatatg atttacagtt tatttttcag ttgtgcacta ttactttaac tgcagaggtt
     6781 atgtcatata tccatagtat gaatagtagt atattagaaa attggaattt tggtgtccct
     6841 ccaccaccta ctacaagttt ggtggataca tatcgttttg tgcaatcagt tgctgttacc
     6901 tgtcaaaagg atactacacc tccagaaaag caggatccat atgataaatt aaagttttgg
     6961 actgttgacc taaaggaaaa attttcctcc gatttggatc aatatcccct tggtcgaaag
     7021 tttttagttc aggctgggtt acgtcgtagg cctaccatag gacctcgtaa gcgtcctgct
     7081 gcttccacgt ctactgcatc tactgcatct aggcctgcca aacgtgtacg tatacgtagt
     7141 aagaaataat atgttagcac atatatgtat gtttgtatgt atggttttgt atgttgtatg
     7201 tatgtatgta tttgtgtgat atattactgt attttgtttg tttgcgtgcg tgtatgtatg
     7261 aatgtgcctt gtggcatgta tggtgttact gtacataatt gtggtattaa ataaagtatg
     7321 ctaatagtgt tgtgtagggt tgcacccttg tgagtaacaa tactatttgt gtgtatgtgt
     7381 attgctttgt accctatatt ctttcctgta tttcaagtta taaacttgca tactacacag
     7441 catccatttt acttataatc ctccattttg ctgtgcaacc gatttcggtt gcctgtggct
     7501 tatatgtgac cttttaaaca taatacctaa actggcacat ttacaacccc tacatagttt
     7561 aacctactgg cgcgccttct tggcgtacat gtggcacacc tggtattagt cattttcctg
     7621 tccaggtgta ctaaaacaat ggcttgcaca actgtatcca caccctatgt aataaaactg
     7681 cttttaggca catattttag tctgttttta cctgtgctaa ttgtataatt ggcgtgtaga
     7741 accactttct tatccaacaa tctgtctact tgttacataa actataaact gactcactta
     7801 tacatacata gtttatgcaa ccgaaaaagg ttgggcccta taacacatac cttttctt
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